Sex-specific genetic effects have been proposed to be an important source of variation for human complex traits. Here we use two distinct genome-wide methods to estimate the autosomal genetic correlation (rg) between men and women for human height and body mass index (BMI), using individual-level (n = ∼44 000) and summary-level (n = ∼133 000) data from genome-wide association studies. Results are consistent and show that the between-sex genetic correlation is not significantly different from unity for both traits. In contrast, we find evidence of genetic heterogeneity between sexes for waist-hip ratio (rg = ∼0.7) and between populations for BMI (rg = ∼0.9 between Europe and the USA) but not for height. The lack of evidence for substantial genetic heterogeneity for body size is consistent with empirical findings across traits and species.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/hmg/ddv443 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of the Relationship Between Facial Measurements and Esthetic Evaluation of the Face in Patients With a Vertical Growth Pattern.
Cureus
January 2025
Department of Orthodontics, School of Dental Sciences, University Sains Malaysia, Kota Bharu, MYS.
Background: Soft tissue specifications and facial values vary depending on the underlying skeletal structures. To achieve the ideal treatment result and patient satisfaction, one must know the attractive soft tissue specifications compatible with each type of malocclusion. This study aims to analyze the facial measurements that contribute to perceived facial attractiveness in patients with vertical growth patterns and skeletal class I malocclusion, focusing on gender-specific differences.
View Article and Find Full Text PDFLow condylectomy and functional therapy alone for unilateral condylar osteochondroma treatment: case report and literature review.
Acta Otorhinolaryngol Ital
December 2024
Orthodontics and Pediatric Dentistry Unit, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Osteochondroma (OC) is a common bone tumour that rarely affects the mandibular condylar process. This pathology can show typical clinical features, such as facial asymmetry, deviation of the chin and dental inferior midline, changes in condylar morphology and malocclusion with an increased posterior mandibular vertical height. The management of condylar OC is a debated topic among surgeons.
View Article and Find Full Text PDFDietary intakes, nutritional and biochemical status of 6 months to 12-year-old children before the COVID-19 pandemic era: the South East Asian Nutrition Survey II Indonesia (SEANUTS II) study in Java and Sumatera Islands, Indonesia.
Public Health Nutr
January 2025
SEANUTS Indonesian Team/Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.
Objective: The South East Asian Nutrition Survey II Indonesia aimed to provide up-to-date data on dietary intake, nutritional and biochemical status of children aged 0·5-12 years in Indonesia 2019-2020.
Design: Multistage cluster sampling, stratified by geographical location.
Setting: Out of forty-six targeted districts in Indonesia, the study only covered twenty-one districts/cities in Java and Sumatera islands, Indonesia due to COVID-19 pandemic.
Impact of cardiac factors on central airway anatomical parameters in patients undergoing lung mass surgery.
J Cardiothorac Surg
January 2025
Department of Thoracic Surgery, The First People's Hospital of Jiande, Jiande, China.
Background: The correlation between central airway anatomical parameters and demographic factors, such as sex, age, weight, height, body mass index (BMI), and cardiac factors, remains unclear. This study examined the correlation between these factors and central airway anatomical parameters in adult patients.
Methods: All consecutive patients who underwent lung mass surgery at our hospital between December 2020 and December 2023 were included in this study.
Clinically meaningful classes of financial toxicity for patients with diabetes.
J Patient Rep Outcomes
January 2025
Department of Physical Medicine and Rehabilitation, University of Michigan, 1540 E. Hospital Dr, Ann Arbor, MI, 48109, USA.
Aims: This study aims to improve the interpretability and clinical utility of the COmprehensive Score for financial Toxicity-Functional Assessment of Chronic Illness Therapy (COST-FACIT) by identifying distinct financial toxicity classes in adults with diabetes.
Methods: Data included a sample of 600 adults with Type 1 or Type 2 diabetes and high A1c. Latent Class Analysis was used to identify subgroups of patients based on COST-FACIT score patterns.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!