Optimal timing of [¹⁸F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects.

Appl Radiat Isot

Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Published: January 2016

To determine the optimal acquisition time of [(18)F]Mefway PET, we examined the regional specific-to-nonspecific binding ratios and evaluated the relationship between distribution volume ratios (DVRs) and standardized uptake value ratios (SUVRs) in various time windows. The specific-to-nonspecific binding ratios peaked after 40 min and there was a strong correlation between DVR and SUVR in the 60-80 min. Therefore, we recommend the use of a single time point between 60 and 80 min for [(18)F]Mefway static PET.

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http://dx.doi.org/10.1016/j.apradiso.2015.10.004DOI Listing

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