Hyperkalemia is a potentially lethal electrolyte derangement commonly seen in patients with hematologic neoplasms with or without renal failure. Pseudohyperkalemia and reverse pseudohyperkalemia also can be seen in this patient population and early recognition and diagnosis of these conditions are vital. Here, we report a case of reverse pseudohyperkalemia in a patient with chronic lymphocytic leukemia (CLL) and provide recommendations regarding diagnostic and therapeutic strategies for management of such patients. Further, we discuss the pathogenesis of this condition and its potential role as a surrogate of favorable prognostic features in patients with CLL.
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http://dx.doi.org/10.1155/2015/930379 | DOI Listing |
Cureus
March 2022
Hematology and Medical Oncology, University of Florida College of Medicine, Jacksonville, USA.
Hyperkalemia is a common electrolyte disorder with potentially life-threatening consequences, including cardiac dysrhythmias. Pseudohyperkalemia must always be ruled out before implementing treatment for true hyperkalemia. Here, we present a case of a 63-year-old male with chronic lymphocytic leukemia (CLL) with a white blood cell count greater than 200 thousand/mm and persistently high serum potassium concentration as high as 8.
View Article and Find Full Text PDFClin Kidney J
May 2021
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Hyperkalemia is a potentially life-threatening electrolyte abnormality that often requires urgent treatment. Clinicians should distinguish true hyperkalemia from pseudohyperkalemia and reverse pseudohyperkalemia (RPK). RPK has exclusively been described in case reports of patients with hematologic malignancies (HMs) and extreme leukocytosis [white blood cell (WBC) count >200 × 10/mL].
View Article and Find Full Text PDFIndian J Clin Biochem
April 2021
Department of Biochemistry, All India Institute of Medical Sciences Patna, Phulwarisharif, Patna, Bihar 801507 India.
Hyperkalemia is a life threatening electrolyte derangement that must be recognized and treated quickly. Pseudohyperkalemia is defined as a difference between serum and plasma potassium concentration of more than 0.4 meq/L with serum values on the higher side when both the samples are obtained at the same time, remain at room temperature and are tested within 1 h of sample collection.
View Article and Find Full Text PDFCureus
August 2020
Internal Medicine, Abington Hospital - Jefferson Health, Abington, USA.
Falsely elevated potassium levels are common in routine laboratory tests and should be differentiated from true hyperkalemia. If the patient is inappropriately treated for hyperkalemia, the resulting hypokalemia can lead to life-threatening cardiac arrhythmias. We present the case of a 67-year-old woman with a past medical history of stable chronic lymphocytic leukemia, who presented for chest pain and had an elevated potassium level of 5.
View Article and Find Full Text PDFClin Biochem
April 2020
Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address:
Objectives: Investigate concomitant and spurious high potassium and low sodium results in heparinized plasma.
Methods: Potassium and sodium values were measured from heparinized plasma and serum in a patient with B-cell non-Hodgkin lymphoma using both an automated chemistry analyzer (indirect ion selective electrode) and blood gas analyzer (direct ion selective electrode).
Results: Potassium levels were significantly increased while sodium levels were significantly decreased in heparinized plasma compared to serum on several occasions.
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