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Unlocking the Potential of miRNAs in Sepsis Diagnosis and Prognosis: From Pathophysiology to Precision Medicine.
J Biochem Mol Toxicol
February 2025
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Cairo, Egypt.
The clinical syndrome appears as a dysregulated host response to infection that results in life-threatening organ dysfunction known as Sepsis. Sepsis is a serious public health concern where for every five deaths in ICU there is one patient who dies with sepsis worldwide. Sepsis is featured as unbalanced inflammation and immunosuppression which is sustained and profound, increasing patient susceptibility to secondary infections and mortality.
View Article and Find Full Text PDFNon-spatial Dynamics and Spatiotemporal Patterns Formation in a Predator-Prey Model with Double Allee and Dome-shaped Response Function.
Bull Math Biol
January 2025
Department of Mathematics, Vivekananda College, Kolkata, West Bengal, 700063, India.
The extinction of species is a major threat to the biodiversity. Allee effects are strongly linked to population extinction vulnerability. Emerging ecological evidence from numerous ecosystems reveals that the Allee effect, which is brought on by two or more processes, can work on a single species concurrently.
View Article and Find Full Text PDF[Description of early deaths of nursing home residents hospitalized after admission in emergency department].
Geriatr Psychol Neuropsychiatr Vieil
December 2024
Service de médecine gériatrique Charles-Nicolle, CHU, Rouen, France, Unirouen, Inserm U1096, Université Normandie, Rouen, France.
A quarter of nursing home residents dies in hospital. Few data are available about early in-hospital deaths of nursing home residents. The aim of the study was to describe the characteristics of early in-hospital deaths of nursing home residents after an admission in emergency department and to identify factors associated with a decision of limitation of care in emergency department.
View Article and Find Full Text PDFReal-world outcomes of first-line maintenance niraparib monotherapy in patients with epithelial ovarian cancer.
Future Oncol
January 2025
Division of Gynecologic Oncology, The Ohio State University Wexner Medical Center and James Hospital Comprehensive Cancer Center, Columbus, OH, USA.
Aims: To assess real-world progression-free survival (rwPFS) and time to next treatment (rwTTNT) among patients with epithelial ovarian cancer (EOC) who received first-line maintenance (1LM) niraparib monotherapy.
Patients & Methods: In this US-nationwide, electronic health record-derived, deidentified database study, eligible patients with EOC initiated 1LM niraparib monotherapy (1 January 2017-1 December 2022) following first-line platinum-based chemotherapy. Median rwPFS and rwTTNT were estimated with Kaplan-Meier methodology overall and in a homologous recombination-deficient (HRd) subgroup (further stratified as wild-type [wt] or -mutated [m]).
Efficacy of liposomal amphotericin B in treating fungal meningitis in AIDS Patients: A review article.
Egypt J Immunol
January 2025
Department of Microbiology and Infection Prevention and Control Unit, Theodor Bilharz Research Institute, Giza 12411, Egypt.
Cryptococcal meningitis is an alarming fungal infection that usually affects the meninges surrounding the brain and spinal cord. The causative organism is Cryptococcus neoformans. Although this infection can occur in normal individuals, it is more often seen in patients with human immunodeficiency virus/acquired immunodeficiency syndrome.
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