AI Article Synopsis
- Researchers developed a nanowire field effect transistor for detecting antibodies against avian influenza in real-time and without labeling.
- The device showed a significant increase in current when anti-AI solutions were applied to it, confirming the presence of these antibodies.
- This technology demonstrates effective antibody-antigen interaction detection and could be utilized in a chip-based biosensor.
Article Abstract
Real-time and label-free detection of antibodies from avian influenza (anti-AI) in an aqueous solution is demonstrated with the use of a nanowire field effect transistor. A real-time measurement system is constructed without leakage paths through the solution medium. The current through the nanowire changes significantly after an injection of an anti-AI solution onto the device, which was previously functionalized by the antigen of AI as a probe of anti-AI. In contrast, no significant response arises when an anti-AI solution is injected onto a non-functionalized device. Therefore, the real-time detection of specific antibody-antigen interaction of the AI is successfully implemented for a chip-based biosensor.
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| http://dx.doi.org/10.1166/jbn.2015.1501 | DOI Listing |
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