An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented. A palladium-catalyzed C-C activation/cross-coupling is utilized to access these structures in a short sequence from (+)-carvone; the scope of this reaction is explored.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.5b02797 | DOI Listing |
Publication Analysis
Top Keywords
natural product-like
8
construction enantiopure
4
enantiopure taxoid
4
taxoid natural
4
product-like scaffolds
4
scaffolds c-c
4
c-c bond
4
bond cleavage/arylation
4
cleavage/arylation reaction
4
reaction approach
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!