AI Article Synopsis
- The Genotype-Tissue Expression (GTEx) project, funded by the NIH, aims to understand how human genetic variations affect gene expression across different tissues in healthy individuals.
- A major challenge was to gather high-quality biological samples, which required building a collaborative infrastructure among researchers for the efficient collection and distribution of tissues, blood, and cell lines.
- This model can be adopted by other research initiatives to partner with autopsy and organ procurement organizations to ensure the collection of quality biospecimens and clinical data, with all GTEx resources available to the broader research community.
Article Abstract
The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project. Other research projects can follow this model and form beneficial partnerships with rapid autopsy and organ procurement organizations to collect high quality biospecimens and associated clinical data for genomic studies. Biospecimens, clinical and genomic data, and Standard Operating Procedures guiding biospecimen collection for the GTEx project are available to the research community.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675181 | PMC |
| http://dx.doi.org/10.1089/bio.2015.0032 | DOI Listing |
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