AI Article Synopsis
- Currently, there are no validated biomarkers to predict how well patients with breast cancer respond to anthracycline treatments.
- The TOP study focused on estrogen receptor-negative tumors and aimed to determine the predictive value of the TOP2A gene and create a gene expression signature for identifying patients unlikely to benefit from anthracyclines.
- The text also includes details on the gene expression and clinical data from the study while offering R code for accessing the dataset and performing quality control and analysis.
Article Abstract
Validated biomarkers predictive of response/resistance to anthracyclines in breast cancer are currently lacking. The neoadjuvant Trial of Principle (TOP) study, in which patients with estrogen receptor (ER)-negative tumors were treated with anthracycline (epirubicin) monotherapy, was specifically designed to evaluate the predictive value of topoisomerase II-alpha (TOP2A) and develop a gene expression signature to identify those patients who do not benefit from anthracyclines. Here we describe in details the contents and quality controls for the gene expression and clinical data associated with the study published by Desmedt and colleagues in the Journal of Clinical Oncology in 2011 (Desmedt et al., 2011). We also provide R code to easily access the data and perform the quality controls and basic analyses relevant to this dataset.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608867 | PMC |
| http://dx.doi.org/10.1016/j.gdata.2013.09.001 | DOI Listing |
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