Introduction: Recurrent hypersomnia (RH) is a rare disorder without established treatment.
Methods: We report 2 RH medication-responsive cases with typical characteristics of Kleine-Levin syndrome (KLS).
Case-reports: A 10 y.o. girl and a 14 y.o. boy presented with sudden sleepiness for 3-9 days (every 2-3 weeks). Physical examination, brain images and blood tests were normal. Polysomnographic findings were heterogenous, including disrupted sleep architecture. MSLTs revealed 2-3 SOREMPs and short sleep latency. Carbamazepine rendered girl׳s sleep normalization, while risperidone normalized boy׳s sleep cycles.
Conclusions: Facing the absence of clinical trials in RH, reports of responsive cases are the available therapeutic evidence.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608889 | PMC |
| http://dx.doi.org/10.1016/j.slsci.2015.06.003 | DOI Listing |
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