AI Article Synopsis
- Iron oxide contrast agents are used with MRI for tracking various cell types, such as stem cells and immune cells.
- This review details properties of the coatings and highlights both ex vivo (outside the body) and in vivo (inside the body) applications of these agents.
- Examples of their use in clinical conditions like stroke and cancer, along with recommendations for study design and validation methods, are also discussed.
Article Abstract
Iron oxide contrast agents have been combined with magnetic resonance imaging for cell tracking. In this review, we discuss coating properties and provide an overview of ex vivo and in vivo labeling of different cell types, including stem cells, red blood cells, and monocytes/macrophages. Furthermore, we provide examples of applications of cell tracking with iron contrast agents in stroke, multiple sclerosis, cancer, arteriovenous malformations, and aortic and cerebral aneurysms. Attempts at quantifying iron oxide concentrations and other vascular properties are examined. We advise on designing studies using iron contrast agents including methods for validation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597836 | PMC |
| http://dx.doi.org/10.4137/MRI.S23557 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-Resolution Free-Breathing Chemical-Shift-Encoded MRI for Characterizing Lymph Nodes in the Upper Abdomen.
Invest Radiol
January 2025
From the Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands (I.T.M., M.C.M., S.Y., R.v.d.E., A.V., E.J.S., J.J.H., T.W.J.S.); and Department of Radiology, NYU Langone Health, New York, NY (T.K.B.).
Objectives: Accurate lymph node (LN) staging is crucial for managing upper abdominal cancers. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging effectively distinguishes healthy and metastatic LNs through fat/water and -weighted imaging. However, respiratory motion artifacts complicate detection of abdominal LNs.
View Article and Find Full Text PDFUse of Magtrace as an Alternative Approach in Staging the Axilla in Early-Stage Breast Cancer: A Single-Center Experience.
Cureus
December 2024
Department of Breast Surgery, The Rotherham NHS Foundation Trust, Rotherham, GBR.
Background The sentinel lymph node biopsy (SLNB) is the standard method used to determine the stage of breast cancer in patients with no clinical signs of axillary involvement. The current gold standard for the intraoperative assessment of the axilla involves the use of dual radioisotope and patent blue dye. However, researchers have been studying the use of superparamagnetic iron oxide Magtrace® (Endomagnetics Limited, Cambridge, United Kingdom) agents as an alternative to overcome the limitations of the standard SLNB technique.
View Article and Find Full Text PDFEnhanced drilling waste-water treatment through magnetic nano-composite coagulant application: A central composite design study.
Heliyon
December 2024
Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran.
A magnetic nano-composite coagulant has been designed, originally applied in a specific industrial waste-water treatment, and statistically investigated using Central Composite Design (CCD). The generated polynomial models were utilized to achieve a comprehensive understanding of the impact of each ingredient of PolyAluminum Chloride (PAC), PolyAcrylAmide (PAM), and Iron (III) oxide magnetic nano particles (MNP) regarding optimum limits and conditions. The concentration of each of those components has been considered as the main effective factors, which are found to be significantly correlated, affecting the Total Dissolved Solid (TDS) removal (%), the Total Suspended Solid (TSS) removal (%), and the Turbidity Reduction Rate (TRR) NTU/min.
View Article and Find Full Text PDFGreen synthesis of low-cost graphene oxide-nano zerovalent iron composite from solid waste for photocatalytic removal of antibiotics.
iScience
December 2024
Enviromicrobiology, Ecotoxicology and Ecotechnology Research Laboratory (3E-MicroToxTech Lab), Department of Ecological Studies, University of Kalyani, Kalyani, Nadia 741235 West Bengal, India.
This study develops a graphene oxide-nano zerovalent iron (GO-nZVI) composite for the efficient removal of tetracycline and ciprofloxacin from water. The composite was synthesized using sugarcane bagasse as the matrix for graphene oxide (GO) and Sal leaf extract to reduce iron into nano zerovalent iron (nZVI). Microscopic analysis confirmed multiple GO layers with nZVI particles on their surface, while XRD and Raman spectroscopy verified the crystalline nature of the composite.
View Article and Find Full Text PDFDesigning iron oxide & silver nanocomposites with phyto- and fungo chemicals for biomedicine: lessons learned.
J Mater Chem B
January 2025
NanoBioMedical Centre, Adam Mickiewicz University in Poznań, 61614 Poznań, Poland.
Multifunctional nanoparticles for biomedical applications are widely researched and constantly developed because they provide wider possibilities for therapy and diagnostics. This work aims to summarise our findings towards the design of multifunctional complex iron oxide and silver nanoparticles (NPs) produced from the plants and and mushrooms and . It was revealed that the antimicrobial and anticancer properties of the NPs were a consequence of the combination of silver and phyto- and fungo-chemicals originating from natural species.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!