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Efficacy of videoconferencing-delivered cognitive behavioural therapy to reduce anxiety disorder severity in LGBTQ+ people: An exploratory trial protocol.
PLoS One
January 2025
Discipline of Clinical Psychology, Graduate School of Health, University of Technology, Sydney, New South Wales, Australia.
Objective: Cognitive behavior therapy (CBT) is a well-established treatment for anxiety disorders in the general population. However, the efficacy of CBT for lesbian, gay, bisexual, transgender, queer, questioning, and otherwise non-heterosexual or non-cisgender (LGBTQ+) people with anxiety disorders is still emerging in the literature. This protocol proposes an exploratory, two-group, randomized controlled trial comparing the efficacy of CBT for anxiety disorders against a waitlist control group.
View Article and Find Full Text PDFTreatment of refractory poly articular course juvenile idiopathic arthritis with tofacitinib: Extended experience from Bangladesh.
PLoS One
January 2025
Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
Background: Juvenile Idiopathic arthritis (JIA) is one of the most common chronic diseases in children. It still remains a challenge to treat refractory poly-articular course JIA patients, especially in Bangladesh, where patients from low socio-economic backgrounds are unable to manage biological agents. Tofacitinib is one of the alternative options to biological agents, which can be taken orally and is cost effective.
View Article and Find Full Text PDFCo-option of mitochondrial nucleic acid-sensing pathways by HSV-1 UL12.5 for reactivation from latent infection.
Proc Natl Acad Sci U S A
January 2025
Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908.
Although viruses subvert innate immune pathways for their replication, there is evidence they can also co-opt antiviral responses for their benefit. The ubiquitous human pathogen, Herpes simplex virus-1 (HSV-1), encodes a protein (UL12.5) that induces the release of mitochondrial nucleic acid into the cytosol, which activates immune-sensing pathways and reduces productive replication in nonneuronal cells.
View Article and Find Full Text PDFAurora B controls microtubule stability to regulate abscission dynamics in stem cells.
Cell Rep
January 2025
Cell Biology, Neurobiology, and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Padualaan, 3584 CS Utrecht, the Netherlands. Electronic address:
Abscission is the last step of cell division. It separates the two sister cells and consists of cutting the cytoplasmic bridge. Abscission is mediated by the ESCRT membrane remodeling machinery, which also triggers the severing of a thick bundle of microtubules.
View Article and Find Full Text PDFEffects of transcutaneous electric nerve stimulation on pain after episiotomy. A systematic review and meta-analysis.
Heliyon
January 2025
Faculty of Physiotherapy, University of Vigo, Pontevedra, Spain.
Background: Episiotomy is a surgical intervention performed during the second stage of labor to facilitate the baby's exit through the birth canal. There are different reasons that lead episiotomy; however, it is recommended performed occasionally and not systematically, since it may produce negative effects such as pain. Different therapies have been described to reduce this pain, including transcutaneous electrical nerve stimulation (TENS).
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