AI Article Synopsis
- Pre-adult crowding conditions can change the fatty acid composition of cell membranes in Drosophila melanogaster, affecting their function and lifespan.
- Adult flies raised in crowded conditions had more polyunsaturated fatty acids, which are more prone to peroxidation, and fewer monounsaturated fatty acids.
- There is a negative link between the peroxidation index and longevity, with long-lived female flies showing lower peroxidation levels compared to control flies under similar density conditions.
Article Abstract
Pre-adult density-associated alterations in the composition of storage lipids may affect the cell membrane fatty acid profile (mainly phospholipids), membrane integrity, and cell function. The present study evaluated the impact of pre-adult density conditions, sex, and the selection regime on the composition of phospholipid fatty acids and lifespan of Drosophila melanogaster. The phospholipid profile of adult flies developed under larval crowding contained a higher proportion of polyunsaturated fatty acids, lower proportion of monounsaturated fatty acids, and greater risk of peroxidation. There was also a negative correlation between the peroxidation index (PI) and longevity. The longevity-selected females showed a lower PI compared with control lines under both densities. The present results indicate that pre-adult density may play a significant role in the lifespan of adult flies by altering the composition of phospholipids and shaping cell membrane bilayers with different susceptibilities to peroxidation.
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| http://dx.doi.org/10.1016/j.exger.2015.10.007 | DOI Listing |
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