Background: The purpose of the experiment was to assess interactions of dopamine with propranolol as an infiltrative anesthetic.
Methods: After injecting the rats with four doses of drugs subcutaneously, the cutaneous analgesic effect of propranolol was compared with dopamine through the blockade of cutaneous trunci muscle reflex (CTMR) in response to local skin pinprick. Drug-drug interactions were examined via an isobolographic analysis.
Results: We demonstrated that the action of propranolol and dopamine was dose dependent to skin infiltrative analgesia. On the ED(50) (50% effective dose) basis, the rank of drug potency was propranolol (11.3 [10.6-12.2]μmol) > dopamine (195 [188-205]μmol) (p < 0.001). At the equi-anesthetic doses (ED(25), ED(50), ED(75)), the block duration caused by dopamine was equal to that caused by propranolol. Coadministration of dopamine and propranolol exhibited a synergistic effect on infiltrative cutaneous analgesia.
Conclusions: The preclinical data showed that dopamine produced a lesser potency but a comparable duration of cutaneous analgesia compared to propranolol. Adding dopamine to propranolol potentiated and prolonged propranolol's cutaneous analgesic effect.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pharep.2015.05.016 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the contribution of the dopaminergic and noradrenergic systems in the antidepressant-like action of 1-(2-(4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethanone in mice.
Behav Brain Res
March 2025
Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS 96010-900, Brazil. Electronic address:
1-(2-(4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethanone (ETAP) is a novel hybrid compound containing 1,2,3-triazole and acetophenone. It exhibits antidepressant-like effects in male mice, linked to modulation of serotonergic receptors and monoamine oxidase A (MAO-A) inhibition. This study aimed to evaluate the involvement of the dopaminergic and noradrenergic systems, as well as MAO-B activity inhibition, in the antidepressant-like effect of ETAP in male mice, and to evaluate the antidepressant-like effect of ETAP in female mice.
View Article and Find Full Text PDFThe negative chronotropic effects of (±)-propranolol and (±)-4-NO-propranolol in the rat isolated right atrium are due to blockade of the 6-nitrodopamine receptor.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), 126 Tessália Vieira de Camargo St, Campinas, São Paulo, 13083-887, Brazil.
The positive chronotropic action induced by 6-nitrodopamine (6-ND) is selectively blocked by β-adrenoceptor antagonists at concentrations that do not affect the positive chronotropic effect induced by dopamine, noradrenaline, and adrenaline. Here, the effects of ( ±)-propranolol, ( ±)-4-NO-propranolol, and ( ±)-7-NO-propranolol were investigated in the rat isolated right atrium. The atrium was mounted in glass chambers containing gassed (95%O:5%CO) and warmed (37 °C) Krebs-Henseleit's solution, and the isometric tension registered (PowerLab system).
View Article and Find Full Text PDFDopamine and Norepinephrine Differentially Mediate the Exploration-Exploitation Tradeoff.
J Neurosci
October 2024
Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455
Article Synopsis
- Dopamine (DA) and norepinephrine (NE) play distinct but overlapping roles in decision-making processes, particularly in the exploration-exploitation tradeoff, where individuals balance trying new options versus sticking with known rewards.
- A study involving male and female mice used a two-armed bandit task to observe how various drugs affecting DA and NE influenced exploration behavior, revealing that increasing DA decreased exploration while decreasing DA had the opposite effect.
- The findings indicate that DA and NE have different mechanisms in regulating exploration, with DA affecting decision noise and NE impacting sensitivity to outcomes, highlighting the complex interplay between these neuromodulators in decision-making.
Contractile effects of stimulation of D-dopamine receptors in the isolated human atrium.
Naunyn Schmiedebergs Arch Pharmacol
August 2024
Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, Magdeburger Straße 4, 06112, Halle (Saale), Germany.
Dopamine receptors have been claimed not to directly increase contractility in the human heart. Therefore, we performed contraction experiments in isolated electrically driven human atrial preparations (HAP). For comparison, we performed contraction experiments with left atrial preparations of transgenic mice which harbor a cardiac overexpression of human D-dopamine receptors (D-TG).
View Article and Find Full Text PDFTips and tricks in tremor treatment.
J Neural Transm (Vienna)
October 2024
Department of Neurology, Philipps University Marburg, Marburg, Germany.
Tremor, whether arising from neurological diseases, other conditions, or medication side effects, significantly impacts patients' lives. Treatment complexities necessitate clear algorithms and strategies. Levodopa remains pivotal for Parkinson's tremor, though response variability exists.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!