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Importance of clinical trials and contributions to contemporary medicine: commentary.
Ann Med
December 2025
Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Clinical trials are crucial to contemporary medicine, offering valuable insights into the safety, efficacy, and appropriate use of new treatments. They contribute to public health improvements, reduce healthcare costs, uncover new understandings of disease biology, and facilitate the development of therapies for rare conditions. Investing in clinical trials is therefore essential for advancing medical science and enhancing patient outcomes globally.
View Article and Find Full Text PDFThe Latarjet procedure is a successful treatment for anterior shoulder instability with less than 5% having redislocations - revision surgery and prior surgery having been shown to be significant risk factors for recurrence. Approximately 90% of athletes return to play after Latarjet, comparable to arthroscopic Bankart repair. Patients may be physically unable to return to play, which may be due to persistent pain, apprehension, or weakness.
View Article and Find Full Text PDFIntegrating Chronic Disease Management and Harm Reduction for Youth with Juvenile Idiopathic Arthritis Amid Canada's Overdose Crisis.
Children (Basel)
November 2024
Section of Rheumatology, Department of Paediatrics, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, 28 Oki Drive NW, Calgary, AB T3B 6A8, Canada.
Juvenile idiopathic arthritis (JIA) is a chronic autoimmune condition in children that often requires long-term pain management, which can include opioid use. In the context of Canada's ongoing overdose crisis, youth with JIA face risks due to potential opioid dependency and exposure to toxic drug supplies. This commentary proposes an integrated approach combining chronic disease management with harm reduction strategies specifically tailored for JIA patients.
View Article and Find Full Text PDFCommentary on the Adaptive Significance of Sociality Around Parturition Events, and Conspecific Support of Parturient Females in Some Social Mammals.
Animals (Basel)
December 2024
School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD, UK.
In recent decades, it has become apparent that during parturition events in a number of social mammals, social support behaviours from group mates can be directed to parturient females (and their newborn neonates). Such behaviour has been documented in diverse taxa, across non-human primates, , , and , living in a range of social group organisations, from matrilineal groups to cooperatively breeding groups and multi-male, multi-female groups. Since sociality, in association with parturition, has been demonstrated to confer several health benefits to human mothers and neonates, here, we also consider the potential adaptive significance of social support behaviours for other, non-human, social mammals.
View Article and Find Full Text PDFThe overlooked role of microbiota-gut-brain communication in child psychiatry: a call for integration in early intervention strategies.
Commun Integr Biol
January 2025
Department of Psychiatry, DeBusk College of Osteopathic Medicine, Harrogate, TN, USA.
Emerging research has highlighted the significant role of microbiota-gut-brain communication in child psychiatric disorders, including autism spectrum disorder (ASD) and anxiety disorders. Despite this, mainstream psychiatric interventions for children continue to focus predominantly on neurological and psychological therapies, neglecting the critical influence of gut microbiota on brain development and behavior. This commentary underscores the need for greater integration of microbiota-targeted therapies, such as dietary interventions, prebiotics, and probiotics, into early psychiatric intervention strategies.
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