CADRs are common and generally have a mild, self-resolving course with minimal associated morbidity and mortality. However, subsets of CARDs are more severe, require intervention, and have significant risk of associated morbidity and mortality. For this reason, it is crucial that the clinician recognize signs and symptoms worrisome for a more severe CARD so that appropriate triage, work-up, and treatment are initiated. In all CADRs the most important first step is identification and withdrawal of the culprit medications.
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