AI Article Synopsis

  • Mini-gastric bypass (MGB) is a safe and effective treatment for patients with type II diabetes and obesity, but its long-term effects for those with a BMI under 35 kg/m² are less understood.
  • A study of 128 patients with BMI 30-35 kg/m² showed significant improvements in diabetes management, with a 95% rate achieving an HbA1c <7% within 6 months and strong remission rates over several years.
  • MGB significantly lowered HbA1c levels over time and resulted in no deaths, though a small percentage faced major complications, highlighting the benefits of early intervention for better long-term outcomes in diabetes control.

Article Abstract

Background: Mini-gastric bypass (MGB) is a safe, effective, and reversible procedure for patients with type II diabetes mellitus (T2DM) and morbid obesity. Less is known, however, about its long-term effects in patients with a body mass index (BMI) <35 kg/m(2).

Methods: From February 2007 to February 2014, 1468 patients underwent MGB at our institution, including 983 with T2DM. Of these, 128 (82 women), of mean age 41.6 ± 10.2 years, had a BMI of 30-35 kg/m(2). Prospectively collected data were analyzed retrospectively. Factors assessed included disease duration, family history, medication use, remission, and biochemical indicators, including fasting plasma glucose, glycosylated hemoglobin (HbA1c), serum insulin, and C-peptide concentrations. Remission of T2DM was defined as HbA1c <6.0 % without medication.

Results: Prior to surgery, patients had a mean BMI of 33.4 ± 3.3 kg/m(2), mean waist circumference of 104.5 ± 8.2 cm, mean C-peptide concentration of 3.4 ± 1.2 ng/ml, and mean T2DM duration of 6.5 ± 3.1 years. Within 6 months of MGB, 95 % of these patients had attained HbA1c <7 %. Complete remission rates at 1, 2, and 7 years were 64, 66, and 53 %, respectively. Mean HbA1c decreased from 10.7 ± 1.5 % at baseline to 6.2 ± 0.5% at 1 year, 5.4 ± 1.2 % at 3 years, and 5.7 ± 1.8 % at 7 years. No deaths occurred, but two (1.6 %) patients experienced major complications.

Conclusions: MGB provides good, long-term control of T2DM in patients with class I obesity. Early intervention results in higher remission rates.

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Source
http://dx.doi.org/10.1007/s11695-015-1941-yDOI Listing

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