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Thyroxine (T3)-mediated regulation of early cardiac repair in a chemical-induced hypoxia/reoxygenation model of adult zebrafish (Danio rerio).
Wound Repair Regen
December 2024
Department of Zoology, Trivenidevi Bhalotia College, Raniganj, West Bengal, India.
Hypoxia-mediated cardiac tissue injury and its repair or regeneration are one of the major health management challenges globally. Unlike mammals, lower vertebrate species such as zebrafish (Danio rerio) represent a natural model to study cardiac injury, repair and regeneration. Thyroxine (T3) has been hypothesised to be one of the endocrine factors responsible for the evolutionary trade-off for acquiring endothermy and regenerative capability in higher vertebrates.
View Article and Find Full Text PDFTesting the sensitivity of the medaka Transgenic Eleuthero-embryonic THYroid-Specific assay (TETHYS) to different mechanisms of action.
Aquat Toxicol
November 2024
Laboratoire WatchFrog S.A., 1 Rue Pierre Fontaine, 91000 Évry, France. Electronic address:
There are many concerns about the impacts of Endocrine-Disrupting Chemicals on both wildlife and human populations. A plethora of chemicals have been shown to interfere with the Hypothalamic-Pituitary-Thyroid (HPT) axis in vertebrates. Disruption of the HPT axis is one of main endocrine criteria considered for the regulation of chemicals, along with the estrogen axis, androgen axis and steroidogenesis (EATS).
View Article and Find Full Text PDFGene biomarkers for the assessment of thyroid-disrupting activity in zebrafish embryos.
Chemosphere
October 2024
Department Ecotoxicogenomics, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Schmallenberg, Germany. Electronic address:
Article Synopsis
- Active ingredients in pesticides and chemicals can harm ecosystems, prompting European laws for chemical risk assessments and banning endocrine disruptors, substances that affect hormone systems.
- Traditional methods to identify thyroid hormone disruptors are expensive and require large numbers of amphibians, highlighting the need for alternative methods that adhere to the 3R principle (replacement, reduction, refinement).
- Our study identified specific biomarker genes in zebrafish embryos exposed to thyroid disruptors, indicating potential for more accurate risk assessments and development of safer chemicals in the future.
Development of a Zebrafish Embryo-Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research.
Environ Toxicol Chem
May 2024
Aquatic Ecology & Toxicology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany.
There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system-disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co-operation and Development (OECD) testing framework. The current OECD approach uses different model organisms for different endocrine modalities, leading to a high number of animal tests.
View Article and Find Full Text PDFIopanoic acid alters thyroid hormone-related gene expression, thyroid hormone levels, swim bladder inflation, and swimming performance in Japanese medaka.
Comp Biochem Physiol C Toxicol Pharmacol
July 2024
Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
Article Synopsis
- The study investigates how iopanoic acid (IOP), a synthetic chemical, disrupts thyroid hormone levels and affects Japanese medaka fish, focusing on gene expression and swimming abilities.
- Exposure to IOP led to a decrease in certain thyroid-related genes and an increase in thyroid hormones T4 and T3, while also impairing swim bladder inflation and swimming performance.
- This research highlights the need for adverse outcome pathways for thyroid hormone disruption in Japanese medaka, similar to those previously established in zebrafish.
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