AI Article Synopsis
- Troxerutin (TRX) is a flavonoid found in common foods that has protective effects against radiation, blood clotting, and damage to kidneys and liver.
- TRX demonstrates the ability to neutralize harmful free radicals like superoxide and nitric oxide, using advanced scientific methods to measure its reactions.
- The compound also protects various cell types from damage caused by free radicals, suggesting its potential as a treatment to combat diseases linked to oxidative stress.
Article Abstract
Troxerutin (TRX) is a flavonoid present in tea, coffee, cereal grains, various fruits and vegetables have been reported to exhibit radioprotective, antithrombotic, nephro and hepato-protective effects. A systematic study was undertaken to evaluate its free radical scavenging ability and anti-apoptotic activity in cell-free and cellular systems. TRX scavenged superoxide, nitric oxide and also other model stable radicals like 1,1-diphenyl-2-picryl-hydazyl, and 2,2'-azinobis3-ethylbenzothiazoline-6-sulfonic acid. It reacted with hydroxyl radicals, carbonate and thiocyanate anions, as evaluated by pulse radiolysis and stopped flow techniques. TRX protected different cell types (epithelial cells, fibroblasts and lymphocytes) against peroxyl radical-induced apoptosis, necrosis and mitotic death. It scavenged intracellular basal and inducible ROS levels and also restored depletion of intracellular GSH levels, suggesting that free radical scavenging ability may be responsible for the observed cytoprotection of different cell types. TRX may find application as an adjuvant in treating various diseases attributed to oxidative stress.
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| http://dx.doi.org/10.1016/j.foodchem.2015.07.078 | DOI Listing |
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