Thirty-three epikeratoplasties were performed on 31 keratoconic contact lens intolerant patients. Thirty-two of these procedures were anatomically successful with clear lenticules and flattening of the postoperative keratometric measurements in all but one eye. One patient's lenticule developed a persistent epithelial defect that eventually required its removal at 42 days. This patient subsequently underwent a successful penetrating keratoplasty. Of the 32 eyes that were anatomically successful, 20 eyes in 19 patients were able to achieve satisfactory visual improvement requiring either no correction or spectacle lenses. Twelve eyes in 11 patients were successfully refit with contact lenses for anisometropic refractive errors (11 eyes) and residual irregular astigmatism (one eye). Three patients (two in the non-contact lens group and one in the contact lens group) have subsequently undergone penetrating keratoplasty for further visual improvement. Our data suggest that the majority of keratoconic epikeratoplasties achieve a satisfactory visual result either unaided or with spectacles; however, those patients who wish to resume contact lens wear may do so successfully.
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http://dx.doi.org/10.1001/archopht.1989.01070010374026 | DOI Listing |
Background: Orthokeratology (OK) contact lenses are increasingly prescribed for myopia control but their impact on corneal epithelial immune cells (CEIC) is unclear. This study compares CEIC in OK wearers to soft contact lens (SCL) wearers and non-wearers.
Methods: In vivo confocal microscope images at the corneal central and mid-peripheral subbasal level were evaluated in 18 OK wearers, 18 SCL wearers and 18 non-wearers (mean age 27.
J Control Release
January 2025
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Republic of Korea. Electronic address:
Although smart contact lenses have demonstrated great potential in theranostics, there remain critical challenges and opportunities in their commercial development. In this Perspective, the current status and capability of smart theranostic contact lenses are highlighted, focusing on their application as sensing systems for detecting biomarkers such as glucose, intraocular pressure (IOP), and inflammatory cytokines, and as drug delivery systems (DDS) for precise and controlled therapy. Additionally, key challenges associated with clinical development and commercialization of smart theranostic contact lenses are discussed, to optimize diagnostic and therapeutic interventions.
View Article and Find Full Text PDFBMC Public Health
January 2025
Department of Research and Development, Central Denmark Region, The Prehospital Emergency Medical Services, Brendstrupgaardsvej 7, Aarhus N, 8200, Denmark.
Background: While most Danish citizens never or very rarely call the national emergency helpline, 1-1-2, a few citizens call very often. In this article, we attend to the often-unheard voices of frequent callers, exploring why these citizens call 1-1-2 and why they often do not feel helped.
Methods: The article is based on a mixed-methods study on citizens in the Central Denmark Region who had called 1-1-2 five or more times during a period of six months in 2023.
Int Ophthalmol
January 2025
Discipline of Optometry, University of KwaZulu-Natal, Durban, South Africa.
Aim: To determine the prevalence of keratoconus and its associated risk factors within the adult population of Trinidad and Tobago.
Method: A population-based cross-sectional study was conducted among adults in Trinidad and Tobago, utilizing the Keratoconus Risk Assessment Questionnaire (KRIS) for data collection. Data were exported to the Statistical Package for Social Sciences (SPSS) version 27 for analysis.
Arq Bras Oftalmol
January 2025
Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Purpose: This study aimed to report the use, efficacy, and safety of intracameral voriconazole as an adjuvant treatment for deep fungal keratitis.
Methods: This was a prospective case series of seven eyes with fungal keratitis with anterior chamber involvement or a corneal ulcer refractory to conventional topical treatment. In addition to topical treatment with 0.
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