New polyanionic modifications of polyamide nucleic acid mimics were obtained. Thymine decamers were synthesized from respective chiral α- and γ-monomers, and their enantiomeric purity was assessed. Here, we present the decamer synthesis, purification and characterization by MALDI-TOF mass spectrometry and an investigation of the hybridization properties of the decamers. We show that the modified γ-S-carboxyethyl-T10 PNA forms a stable triplex with polyadenine DNA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607454 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140468 | PLOS |
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