Two consecutive cases of symptomatic vitreomacular adhesion with macular hole were treated with intravitreal ocriplasmin. Both were complicated by long-term visual symptoms and chronic serous foveal detachments lasting 17 months post-treatment. These findings suggest direct and long-lasting effects of ocriplasmin on the retinal pigment epithelium and/or outer retina. Patients treated with ocriplasmin should be cautioned that the side effects of even successful drug treatment may prolong visual recovery compared to vitrectomy.
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