Temporomandibular joint derangement is a common disorder of the stomatognathic system. One type of these disorders is disc displacement without reduction with limited mouth opening, characterized by pain in affected TMJ and a decreased range of mouth opening. The natural course of closed lock is self-limiting. However, if there is no significant improvement after 12 weeks of following natural course of disc displacement without reduction, this is an indication that the therapy should be implemented. The article presents a review of the most commonly applied methods of basic conservative closed lock treatment. The most commonly applied methods of closed lock conservative management are: education and counseling, mandibular manipulation, splint therapy, exercise therapy and pharmacotherapy. The first choice method of treatment should be minimally invasive. The surgical management should be considered after unsuccessful conservative therapy. All presented methods of closed lock treatment seem to be effective in decreasing pain and reestablishing physiological range of motion.
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http://dx.doi.org/10.17219/acem/35165 | DOI Listing |
bioRxiv
December 2024
Istanbul Medipol University, School of Engineering and Natural Sciences, Department of Biomedical Engineering, 34810, Istanbul, Turkey.
G protein-coupled receptor (GPCR) signaling is terminated by arrestin binding to a phosphorylated receptor. Binding propensity has been shown to be modulated by stabilizing the pre-activated state of arrestin through point mutations or C-tail truncation. Here, we hypothesize that pre-activated rotated states can be stabilized by small molecules, and this can promote binding to phosphorylation-deficient receptors, which underly a variety of human disorders.
View Article and Find Full Text PDFJ Craniofac Surg
December 2024
Oral and Maxillofacial Radiology, Ain Shams University. Oral and Maxillofacial Radiology, Badr University in Cairo.
Purpose: This study aimed at comparing the therapeutic effect of nalbuphine in comparison to morphine after Temporomandibular joint (TMJ) arthrocentesis in patients with anterior disc displacement without reduction (ADDwoR).
Materials And Methods: Twenty-four female patients diagnosed with ADDwoR. Patients were treated with TMJ arthrocentesis then randomly divided into parallel groups.
mSphere
December 2024
Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Unlabelled: Bacterial pathogens remain poorly characterized in bats, especially in North America. We describe novel (and in some cases panmictic) hemoplasmas (10.1% positivity) and bartonellae (25.
View Article and Find Full Text PDFJ Clin Orthop Trauma
December 2024
Department of Orthopaedic and Trauma Surgery Department, British Hospital of Buenos Aires, Buenos Aires Argentina, Perdriel 74, C1280 AEB, Buenos Aires, Argentina.
Background: Although the intramedullary nail represents the treatment for most tibia diaphyseal fractures, there is no agreement on the configuration of the distal locking screws. Therefore, this study aimed to investigate the impact of the configuration of distal locking bolts on the healing of a tibial shaft fracture.
Methods: We retrospectively analyzed 170 closed fractures of the tibia diaphyseal operated consecutively between 2018 and 2021.
Front Neuroinform
November 2024
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany.
We introduce an open-source Python package for the analysis of large-scale electrophysiological data, named SyNCoPy, which stands for Systems Neuroscience Computing in Python. The package includes signal processing analyses across time (e.g.
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