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GelMA Hydrogels Integrated With aptamer CH6-Functionalized Tetrahedral DNA Nanostructures for Osteoporotic Mandibular Regeneration.
Macromol Biosci
January 2025
Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, 200011, China.
Osteoporotic bone regeneration is challenging due to impaired bone formation. Tetrahedral DNA nanostructures (TDN), promising nucleic acid nanomaterials, have garnered attention for their potential in osteoporotic mandibular regeneration owing to their ability to enhance cellular activity and promote osteogenic differentiation. Osteoblasts play a critical role in bone regeneration; however, intracellular delivery of TDN into osteoblasts remains difficult.
View Article and Find Full Text PDFFGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia.
Bone Res
January 2025
Université de Paris Cité, Imagine Institute, Laboratory of Molecular and Physiopathological Bases of Osteochondrodysplasia, INSERM UMR 1163, Paris, France.
Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes lead to chondrodysplasia and craniosynostoses. FGFR signaling has a key role in the formation and repair of the craniofacial skeleton. Here, we analyzed the impact of Fgfr2- and Fgfr3-activating mutations on mandibular bone formation and endochondral bone repair after non-stabilized mandibular fractures in mouse models of Crouzon syndrome (Crz) and hypochondroplasia (Hch).
View Article and Find Full Text PDFRadiomorphometric Parameters in Mandibular Panoramic Radiographs of Hypothyroid Patients: A Cross-Sectional Study.
Clin Cosmet Investig Dent
January 2025
Department of Conservative Dentistry and Endodontics, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Purpose: Thyroid hormones have a catabolic effect on bone mineral homeostasis. Hypothyroid patients have shown changes in bone mineral density with increased risk for osteoporosis and bone fractures. Radiomorphometric parameters on panoramic images are good indicators of bone mineral density.
View Article and Find Full Text PDFRole of decompression in pediatric mandibular odontogenic keratocyst.
Natl J Maxillofac Surg
November 2024
Kasturba Medical College, Manipal, Karnataka, India.
Special care is required for the management of jaw lesions in pediatric population. The following article describes the decompression technique as the least aggressive approach for the management of pediatric mandibular odontogenic keratocyst. A custom-made acrylic splint was fabricated around teeth, and it was attached to a piece of Foley's catheter to be used as a decompression port.
View Article and Find Full Text PDFTemplate for positioning miniplates (PUNPLAPOT-M) on mandibular symphysis: Novel innovation.
Natl J Maxillofac Surg
November 2024
Fellow of International Association of Oral and Maxillofacial Surgeons, Chicago, USA.
Purpose: This study was conducted to check the efficacy of PUNPLAPOT-innovative Template for positioning of the bone miniplate for fracture fixation.
Material And Methods: Twenty dried mandible specimens were used in this study. The specimens were then divided into two groups using random sampling.
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