Multifunctional hybrid-design nanomaterials appear to be a promising route to meet the current therapeutics needs required for efficient cancer treatment. Herein, two efficient heat nano-generators were combined into a multifunctional single nanohybrid (a multi-core iron oxide nanoparticle optimized for magnetic hyperthermia, and a gold branched shell with tunable plasmonic properties in the NIR region, for photothermal therapy) which impressively enhanced heat generation, in suspension or in vivo in tumours, opening up exciting new therapeutic perspectives.
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http://dx.doi.org/10.1039/c5nr06168g | DOI Listing |
Biomed Eng Online
August 2023
Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran.
Background: Nano-photothermal therapy (NPTT) has gained wide attention in cancer treatment due to its high efficiency and selective treatment strategy. The biggest challenges in the clinical application are the lack of (i) a reliable platform for mapping the thermal dose and (ii) efficient photothermal agents (PTAs). This study developed a 3D treatment planning for NPTT to reduce the uncertainty of treatment procedures, based on our synthesized nanohybrid.
View Article and Find Full Text PDFPharmaceutics
January 2022
Laboratoire Physico Chimie Curie, Institut Curie, CNRS, PSL Research University, 75005 Paris, France.
Nanoparticles (NPs) are at the leading edge of nanomedicine, and determining their biosafety remains a mandatory precondition for biomedical applications. Herein, we explore the bioassimilation of copper sulfide NPs reported as powerful photo-responsive anticancer therapeutic agents. The nanoparticles investigated present a hollow shell morphology, that can be left empty (CuS NPs) or be filled with an iron oxide flower-like core (iron oxide@CuS NPs), and are compared with the iron oxide nanoparticles only (iron oxide NPs).
View Article and Find Full Text PDFSmall
March 2020
Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057, CNRS and Université Paris Diderot, 75205, Paris cedex 13, France.
Progress of thermal tumor therapies and their translation into clinical practice are limited by insufficient nanoparticle concentration to release therapeutic heating at the tumor site after systemic administration. Herein, the use of Janus magneto-plasmonic nanoparticles, made of gold nanostars and iron oxide nanospheres, as efficient therapeutic nanoheaters whose on-site delivery can be improved by magnetic targeting, is proposed. Single and combined magneto- and photo-thermal heating properties of Janus nanoparticles render them as compelling heating elements, depending on the nanoparticle dose, magnetic lobe size, and milieu conditions.
View Article and Find Full Text PDFNanomaterials (Basel)
February 2020
Université de Paris, ITODYS, CNRS, UMR 7086, 15 rue J-A de Baïf, 75013 Paris, France.
In this work, the preparation of magneto-plasmonic granular nanostructures and their evaluation as efficient substrates for magnetically assisted surface enhanced Raman spectroscopy (SERS) sensing are discussed. These nanostructures consist of star-shaped gold Au shell grown on iron oxide FeO multicores. They were prepared by seed-mediated growth of anisotropic, in shape gold nanosatellites attached to the surface of polyol-made iron oxide polycrystals.
View Article and Find Full Text PDFJ Pharm Sci
December 2018
Department of Physics, Sharif University of Technology, P.O. Box 11365-9567, Tehran, Iran. Electronic address:
Three magneto-plasmonic nanohybrids were synthesized using Au- and Ag-coated FeO nanoparticles (NPs)-modified dual pH- and temperature-responsive triblock copolymer of poly (butyl methacrylate-co-acrylamide-co-methacrylic acid) to serve as drug carriers with potential of using in both photothermal and controlled/targeted chemotherapies. The internal superparamagnetic core gives the carriers targeted-delivery characteristics, and surface plasmon resonance-based noble metallic Au/Ag shells give them on-demand photothermal and photo-triggering release properties. To investigate the effect of coating method on the targeting property of synthesized carriers, Au NPs were attached to the magnetic core by 2 different direct/indirect procedures and the properties of the synthesized carriers including swelling ratio and thermal and optical sensitivity and switching were comprehensively investigated in 2 different buffer solutions with pH 5.
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