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Effect of intermittent water flow on biodegradation of organic micropollutants in the hyporheic zone.
Chemosphere
January 2025
HydroSciences Montpellier, University of Montpellier, IRD, CNRS, 15 Av. Charles Flahault 34090, Montpellier, France.
Water scarcity in the Mediterranean area has increased the number of intermittent rivers. Recently, hyporheic zones (HZ) of intermittent rivers have gained attention since a substantial part of the stream's natural purification capacity is located within these zones. Thus, understanding the flow dynamics in HZs is crucial for gaining insights into the degradation of organic micropollutants.
View Article and Find Full Text PDFAssessing the prevalence of anticholinergic and sedative medications to avoid in older adults from the French Health Data System.
J Am Geriatr Soc
January 2025
Department of Pharmacy, Charpennes Hospital, Hospices Civils de Lyon, Villeurbanne, France.
Background: In older people, medications with anticholinergic or sedative properties are associated with falls, frailty, and functional and cognitive impairment. These medications are often described as a subset of potentially inappropriate medications (PIMs). We examined the prevalence of anticholinergic or sedative medications to avoid in older people in France in 2023.
View Article and Find Full Text PDFPiperazine-based P2X4 receptor antagonists.
Arch Pharm (Weinheim)
January 2025
European Institute for Molecular Imaging (EIMI), University of Muenster, Muenster, Germany.
The P2X4 receptor (P2X4R), a ligand-gated ion channel activated by ATP, plays a critical role in neuroinflammation, chronic pain, and cancer progression, making it a promising therapeutic target. In this study, we explored the design and synthesis of piperazine-based P2X4R antagonists, building on the structural framework of paroxetine. A series of over 35 compounds were synthesized to investigate structure-activity relationships (SARs) in a Ca²⁺-flux assay for P2X4R antagonistic activity.
View Article and Find Full Text PDFParoxetine promotes longevity via ser-7-dop-4-IIS axis in Caenorhabditis elegans.
Geroscience
December 2024
Center for Aging Biomedicine, College of Life Sciences, National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, Hunan Normal University, 36 Lushan Road, Changsha, 410081, Hunan, China.
Paroxetine, a selective serotonin reuptake inhibitor, is widely used in the clinical treatment of depression. While several antidepressants show promise as geroprotectors, the role of paroxetine in aging remains unclear. In this study, we evaluated the lifespan extension effect of paroxetine in Caenorhabditis elegans (C.
View Article and Find Full Text PDFEarly-Phase Intervention With Traditional Japanese Acupuncture and Moxibustion for Fibromyalgia: A Case Report.
Cureus
November 2024
Department of Traditional Medicine, Toho University, Tokyo, JPN.
Fibromyalgia (FM) is a common chronic pain with no established treatment. Acupuncture is an expected treatment for FM though a diagnosis of FM tends to be delayed, and the advantage is still unclear in early-phase intervention with acupuncture treatment for FM. A 51-year-old woman with panic disorder presented with a four-month history of whole-body pain and was diagnosed with FM.
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