AI Article Synopsis

  • The study focused on finding out how certain gene variations (polymorphisms) are linked to recurrent pregnancy loss (RPL) in obese and lean Egyptian women.
  • Researchers looked at 120 women with RPL and 120 healthy women, using tests to analyze specific gene polymorphisms and measure levels of IL-17 and leptin in their blood.
  • Findings revealed that one gene variant (IL-17 F rs763780) reduces the risk of RPL, while two others (IL-17 A rs2275913 and leptin 2548 G/A) increase the risk; both IL-17 and leptin levels were higher in women experiencing RPL, especially among those who were obese.

Article Abstract

Recurrent pregnancy loss (RPL) is a common problem during early gestation. The aim of our study was to investigate the association of IL-17 F( rs763780), IL-17 A (rs2275913), and leptin (2548 G/A) gene polymorphisms with RPL in obese and lean Egyptian females, and to find out whether these gene polymorphisms affect the women’s serum levels. One hundred and twenty patients with RPL and 120 fertile volunteers with no history of pregnancy loss were genotyped for leptin (2548 G/A), IL-17 A (rs2275913), and IL-17 F (rs763780) polymorphisms by RFLP. The serum level of IL-17 was measured by ELISA, while serum leptin level was measured by HPLC. We found that IL-17 F (rs763780) polymorphism was associated with a decreased risk of RPL in Egyptian females, and we also found that IL-17 A (rs2275913) and LEP (2548 G/A) SNP were associated with an increased risk of RPL. We also demonstrated that both the IL-17 and leptin levels were elevated in the women with RPL and in an obese subgroup within RPL in comparison to a lean one.

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http://dx.doi.org/10.1007/s00251-015-0876-8DOI Listing

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