The cognate facilitation effect refers to the phenomenon that in bilinguals performance on various vocabulary tasks is enhanced for cross-linguistic cognates as opposed to noncognates. However, research investigating the presence of the cognate advantage in bilingual children remains limited. Most studies with children conducted to date has not included a control group or rigorously designed stimuli, which may jeopardize the validity and robustness of the emerging evidence. The current study addressed these methodological problems by examining performance in picture naming tasks in 34 4- to 7-year-old Spanish-English bilinguals and 52 Mandarin-English bilinguals as well as 37 English-speaking monolinguals who served as controls. Stimuli were controlled for phonology, word frequency, and length. The Spanish-English bilinguals performed better for cognates than for noncognates and exhibited a greater number of doublet responses (i.e., providing correct responses in both languages) in naming cognate targets than in naming noncognates. The control groups did not show differences in performance between the two sets of words. These findings provide compelling evidence that cross-linguistic similarities at the phonological level allow bootstrapping of vocabulary learning.
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http://dx.doi.org/10.1016/j.jecp.2015.09.007 | DOI Listing |
BMC Biol
December 2024
Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Background: Molecular interactions between proteins and their ligands are important for drug design. A pharmacophore consists of favorable molecular interactions in a protein binding site and can be utilized for virtual screening. Pharmacophores are easiest to identify from co-crystal structures of a bound protein-ligand complex.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, China. Electronic address:
Chaperone mediated autophagy (CMA) represents a specialized mechanism of lysosomal protein breakdown, playing a crucial role as a metabolic pathway that helps to regulate and sustain cellular and systemic physiological equilibrium. Within the CMA process, proteins that contain sequences similar to KFERQ are specifically identified by the heat shock cognate protein 70. These proteins are then chaperoned to the lysosomes for subsequent degradation, a process facilitated by the lysosome associated membrane protein 2A.
View Article and Find Full Text PDFFEBS J
December 2024
Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Canada.
Aminoacyl-tRNA synthetases catalyze the ligation of a specific amino acid to its cognate tRNA. The resulting aminoacyl-tRNAs are indispensable intermediates in protein biosynthesis, facilitating the precise decoding of the genetic code. Pathogenic alleles in the aminoacyl-tRNA synthetases can lead to several dominant and recessive disorders.
View Article and Find Full Text PDFBrain Struct Funct
December 2024
Brown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Sciences Center-Houston, Houston, TX, USA.
Corticotropin-releasing hormone (CRH) signaling through its cognate receptors, CRHR1 and CRHR2, contributes to diverse stress-related functions in the mammalian brain. Whereas CRHR2 is predominantly expressed in choroid plexus and blood vessels, CRHR1 is abundantly expressed in neurons in discrete brain regions, including the neocortex, hippocampus and nucleus accumbens. Activation of CRHR1 influences motivated behaviors, emotional states, and learning and memory.
View Article and Find Full Text PDFMicrobiol Res
November 2024
Department of Plant Pathology, MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China. Electronic address:
Robust biofilm formation on host niches facilitates beneficial Bacillus to promote plant growth and inhibit plant pathogens. Arginine kinase McsB is involved in bacterial development and stress reaction by phosphorylating proteins for degradation through a ClpC/ClpP protease. Conversely, cognate arginine phosphatase YwlE counteracts the process.
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