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Strategies for Influenza Outbreak Management in a US Residential Summer Camp Communal Housing: A Comparative Analysis of Targeted Antiviral Prophylaxis.
J Community Health Nurs
January 2025
Department of Public Health, University of North Florida, Jacksonville, Florida.
Background: Previous research has underscored the efficacy of individual control strategies in mitigating influenza spread within communal settings; however, the unique dynamics of residential summer camps-characterized by close contact and high social interaction-present distinct challenges for outbreak management.
Purpose: The purpose of this study was to evaluate and compare the effectiveness of two targeted antiviral prophylaxis protocols using oseltamivir in controlling influenza outbreaks within a residential youth camp, aiming to provide evidence-based insights for optimizing outbreak management in communal settings with high social interaction.
Design: This retrospective study analyzed the progression of influenza outbreaks in a residential youth camp using two antiviral prophylaxis protocols with oseltamivir.
Antiviral Medications for Treatment of Nonsevere Influenza: A Systematic Review and Network Meta-Analysis.
JAMA Intern Med
January 2025
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Importance: The optimal antiviral drug for treatment of nonsevere influenza remains unclear.
Objective: To compare effects of antiviral drugs for treating nonsevere influenza.
Data Sources: MEDLINE, Embase, CENTRAL, CINAHL, Global Health, Epistemonikos, and ClinicalTrials.
A Novel Molecularly Imprinted Electrochemiluminescence Sensor Based on Mxene Quantum Dots for Selective Detection of Oseltamivir in Biological Samples.
Molecules
January 2025
School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China.
Oseltamivir is a drug that has been widely used to prevent and treat influenza A and B. In this work, an ultrasensitive, simple, and novel electrochemiluminescence (ECL) sensor combined with molecularly imprinted polymers (MIP-ECL) based on a graphene-like two-dimensional material, Mxene quantum dots (MQDs) was constructed to selectively detect oseltamivir. A molecularly imprinted polymer membrane containing an oseltamivir template was constructed by electropolymerization and elution of modified MQDs on a glassy carbon electrode.
View Article and Find Full Text PDFIncidence of severe illness in pediatric influenza outpatients treated with baloxavir or neuraminidase inhibitors.
J Infect Chemother
January 2025
Global Development Division, Shionogi & Co., Ltd., Osaka, Japan. Electronic address:
Introduction: A single oral dose of baloxavir marboxil, a cap-dependent endonuclease inhibitor, is approved for patients with influenza A or B infection; however, real-world evidence is limited. We evaluated the effectiveness of baloxavir vs neuraminidase inhibitors in reducing the incidence of severe illness in influenza outpatients aged 5-11 years.
Methods: In this retrospective cohort study, we analyzed individual-level data from patients treated with these antivirals, using a large, Japanese health insurance claims database (JMDC).
Influenza and Aging: Clinical Manifestations, Complications, and Treatment Approaches in Older Adults.
Drugs Aging
January 2025
University Hospitals of Cleveland, 11100 Euclid Ave, Mailstop 5083, Cleveland, OH, 44106, USA.
Influenza, a highly contagious respiratory viral illness, poses significant global health risks, particularly affecting older and those with chronic health conditions. Influenza viruses, primarily types A and B, are responsible for seasonal human infections and exhibit a propensity for antigenic drift and shift, contributing to seasonal epidemics and pandemics. The severity of influenza varies, but severe cases often lead to pneumonia, acute respiratory distress syndrome, and multiorgan failure.
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