Nineteen glaucoma patients, 17 ocular hypertensives, and 16 normal subjects underwent visual field testing on the Humphrey Field Analyzer using two programs: full threshold (thresholding of all test points with double-crossing technique) and quantification of defects (thresholding only points that deviated more than 6 dB from a presumed normal retinal contour). The purpose of the study was to compare the diagnostic value of information gained by the latter, less time-consuming test with that of the full threshold procedure. The average time requirement per eye was 13 min 11 s for full thresholding and 4 min 22 s for quantification of defects. Of the 104 sets of fields, the diagnosis was at variance in 18. The differences were most often due to shallow defects in otherwise normal fields or shallow defects surrounding deeper scotomas that had been detected by both programs. The shallow defects placed the fields in more advanced diagnostic categories and were all detected with the full threshold technique.
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http://dx.doi.org/10.1007/BF02169826 | DOI Listing |
Neuromodulation
January 2025
Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Objectives: Biphasic sinusoidal repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation treatment that has been approved by the US Food and Drug Administration for treatment-resistant depression (TRD). Recent advances suggest that standard rTMS may be improved by altering the pulse shape; however, there is a paucity of research investigating pulse shape, owing primarily to the technologic limitations of currently available devices. This pilot study examined the feasibility, tolerability, and preliminary efficacy of biphasic and monophasic rectangular rTMS for TRD.
View Article and Find Full Text PDFHealthcare (Basel)
December 2024
LA-REAL, Comprehensive Health Research Centre (CHRC), University of Évora, 7000-811 Évora, Portugal.
Unlabelled: The global ageing population faces rising depression rates due to social, economic, and health changes. Depression in older adults, often linked to isolation and health issues, requires comprehensive care. Psychotherapeutic interventions could be effective in reducing symptoms, offering personalized and holistic support.
View Article and Find Full Text PDFMicrosc Res Tech
January 2025
School of Electrical & Control Engineering, Shenyang Jianzhu University, Shenyang, China.
The atomic force microscope (AFM) image will be inclined and bent due to the tilt angle between the probe and the sample surface. When the least squares fitting method is used to correct the horizontal distortion of the AFM image, the shape structure that is lower or higher than the sample base will affect the final fitting correction result. In view of the limitations of existing methods and the diversity of AFM images, an AFM image level distortion correction method based on automatic feature marking is proposed.
View Article and Find Full Text PDFTruncated TrkB (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral sensory neurons, particularly nociceptors. Furthermore, sensory neuronal TrkB expression and function has been traditionally associated with non-nociceptive neurons, particularly Aδ low-threshold mechanoreceptors. This study challenges prevailing assumptions by demonstrating that TrkBT1 is the predominant TrkB isoform expressed in sensory neurons and plays a functional role in modulating neuronal activity.
View Article and Find Full Text PDFInfect Drug Resist
January 2025
Department of Immunology and Rheumatology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, People's Republic of China.
Purpose: Sepsis-associated liver injury (SALI) leads to increased mortality in sepsis patients, yet no specialized tools exist for early risk assessment. This study aimed to develop and validate a risk prediction model for early identification of SALI before patients meet full diagnostic criteria.
Patients And Methods: This retrospective study analyzed 415 sepsis patients admitted to ICU from January 2019 to January 2022.
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