This research paper is aimed at studying the total synthesis of pharmacologically active lignan (-)-hinokinin. The synthesis features a three-step cascade reaction involving highly stereoselective Michael addition, anion-oxidative hydroxylation, and oxygen anion cyclization to construct the pivotal butyrolactonimidate intermediate.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607678 | PMC |
| http://dx.doi.org/10.1007/s13659-015-0073-3 | DOI Listing |
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