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Purpose: To observe the changes in peripapillary retinal nerve fiber layer (RNFL) thickness and peripapillary vessel densities (VD) in patients with rhegmatogenous retinal detachment (RRD) after scleral buckling (SB) by OCTA.
Methods: A total of 40 patients (40 eyes) with monocular RRD who underwent SB were included in the study, with the operated eyes (40 eyes) as the study group and the contralateral healthy eyes (40 eyes) as the control to analyse the changes in peripapillary RNFL thickness and VD before and after surgery. Data were analysed by paired samples -test or Wilcoxon signed rank sum test.
Late-Onset Ocular Hypotensive Effect of Ripasudil on Primary Open-Angle Glaucoma.
Clin Ophthalmol
December 2024
Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.
Purpose: We evaluated the late-onset ocular hypotensive effect of ripasudil after long-term administration in real-world clinical data and investigated its associated factors in primary open-angle glaucoma (POAG).
Patients And Methods: We reviewed the clinical patients with POAG who newly started ripasudil without changes of treatment. Enrolled eyes were assigned to two groups: positive group with the late-onset effect and negative group.
Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration.
Acta Neuropathol Commun
December 2024
Department of Ophthalmology, UPMC Vision Institute, University of Pittsburgh School of Medicine, 1622 Locust Street, Pittsburgh, PA, 15219, USA.
Mammalian central nervous system (CNS) axons cannot spontaneously regenerate after injury, creating an unmet need to identify molecular regulators to promote axon regeneration and reduce the lasting impact of CNS injuries. While tubulin polymerization promoting protein family member 3 (Tppp3) is known to promote axon outgrowth in amphibians, its role in mammalian axon regeneration remains unknown. Here we investigated Tppp3 in retinal ganglion cells (RGCs) neuroprotection and axonal regeneration using an optic nerve crush (ONC) model in the rodent.
View Article and Find Full Text PDFComparison of functional, structural and vascular characteristics between dominant and nondominant eyes.
Doc Ophthalmol
December 2024
Department of Ophthalmology, Bilkent City Hospital, Ankara, Turkey.
Purpose: The aim of this study was to compare retinal and optic disc functions as well as vascular structures in dominant eyes (DE) and non-dominant eyes (NDE) among healthy adults using pattern electroretinogram (PERG), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) tests.
Methods: Seventy-two eyes of 36 healthy subjects with bilateral visual acuity of 1.0 were included.
Normative prospective data on automatically quantified retinal morphology correlated to retinal function in healthy ageing eyes by two microperimetry devices.
Acta Ophthalmol
December 2024
Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Purpose: The relationship between retinal morphology, as assessed by optical coherence tomography (OCT), and retinal function in microperimetry (MP) has not been well studied, despite its increasing importance as an essential functional endpoint for clinical trials and emerging therapies in retinal diseases. Normative databases of healthy ageing eyes are largely missing from literature.
Methods: Healthy subjects above 50 years were examined using two MP devices, MP-3 (NIDEK) and MAIA (iCare).
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