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Expression of the large amino acid transporter SLC7A5/LAT1 on immune cells is enhanced in primary sclerosing cholangitis-associated cholangiocarcinoma and correlates with poor prognosis in cholangiocarcinoma.
Hum Pathol
November 2024
Institute of Pathology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. Electronic address:
Biliary tract cancers (BTC) are rare lethal malignancies arising along the biliary tree. Unfortunately, effective therapeutics are lacking and the prognosis remains dismal even for patients eligible for surgical resection. Therefore, novel therapeutic approaches along with early detection strategies and prognostic markers are urgently needed.
View Article and Find Full Text PDFVirtual multiplexed immunofluorescence staining from non-antibody-stained fluorescence imaging for gastric cancer prognosis.
EBioMedicine
September 2024
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA. Electronic address:
Background: Multiplexed immunofluorescence (mIF) staining, such as CODEX and MIBI, holds significant clinical value for various fields, such as disease diagnosis, biological research, and drug development. However, these techniques are often hindered by high time and cost requirements.
Methods: Here we present a Multimodal-Attention-based virtual mIF Staining (MAS) system that utilises a deep learning model to extract potential antibody-related features from dual-modal non-antibody-stained fluorescence imaging, specifically autofluorescence (AF) and DAPI imaging.
Hematoxylin and Eosin Architecture Uncovers Clinically Divergent Niches in Pancreatic Cancer.
Tissue Eng Part A
October 2024
Hagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA.
Pancreatic ductal adenocarcinoma (PDAC) represents one of the only cancers with an increasing incidence rate and is often associated with intra- and peri-tumoral scarring, referred to as desmoplasia. This scarring is highly heterogeneous in extracellular matrix (ECM) architecture and plays complex roles in both tumor biology and clinical outcomes that are not yet fully understood. Using hematoxylin and eosin (H&E), a routine histological stain utilized in existing clinical workflows, we quantified ECM architecture in 85 patient samples to assess relationships between desmoplastic architecture and clinical outcomes such as survival time and disease recurrence.
View Article and Find Full Text PDFExploring the Role of Circulating Cell-Free RNA in the Development of Colorectal Cancer.
Int J Mol Sci
July 2023
Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Article Synopsis
- Circulating tumor RNA (ctRNA) is a promising new liquid biomarker that can provide valuable noninvasive insights into gene expression related to cancer, eliminating the need for traditional tissue biopsies.
- The research highlights how higher levels of cancer-specific ctRNA can enhance detection and analyze conditions where circulating tumor DNA (ctDNA) is insufficient.
- The review also covers the current understanding of ctRNAs in colorectal cancer diagnosis and treatment, along with practical considerations for analyzing plasma ctRNA, including storage, isolation, and detection methods.
Cell-free circulating tumor RNAs in plasma as the potential prognostic biomarkers in colorectal cancer.
Front Oncol
April 2023
R&D, Codex Genetics Limited, Hong Kong, Hong Kong SAR, China.
Background: Cell free RNA (cfRNA) contains transcript fragments from multiple cell types, making it useful for cancer detection in clinical settings. However, the pathophysiological origins of cfRNAs in plasma from colorectal cancer (CRC) patients remain unclear.
Methods: To identify the tissue-specific contributions of cfRNAs transcriptomic profile, we used a published single-cell transcriptomics profile to deconvolute cell type abundance among paired plasma samples from CRC patients who underwent tumor-ablative surgery.
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