Objective: To investigate the different types of obesity, insulin resistance (IR) and its related adipocytokines, and to analyze the association of adipocytokines with obesity and insulin resistance in Korean-Chinese and Han nationality pupils of Yanbian area.
Methods: A total of 3879 elementary school students (2011 of Korean-Chinese and 1868 of Han nationality) aged 8-12 years old were selected. Using epidemiological investigation. Combined with laboratory measurement, the body mess index ( BMI), waist circumference (WC) and fasting blood glucose (FBG), insulin, adiponectin, leptin and tumor necrosis factor-alpha (TNF-α) levels were measured. The homeostasis model assessment (HOMA) method was used to estimate the human IR (HOMA-IR).
Results: (1) The levels of adiponctin and TNF-α in Korean-Chinese pupils was lower than that in Han nationality pupils (P < 0.01), and the levels of leptin, HOMA-IR, WC and BMI in Korean-Chinese pupils were higher than that in Han nationality pupils (P < 0.01). (2) BMI, WC and HOMA-IR was negatively related with adiponectin (r = -0.178, -0.172 and -0.137, P < 0.001), and that were positively related with leptin (r = 0.572, 0.535 and 0.265, P < 0.001) and TNF-α (r = 0.110, 0.119 and 0.691, P < 0.001). There were nationality differences in the correlation of BMI, WC ard HOMA-IR in the different adipocytokines. (3) The multivariate regression analysis showed that there was a significant linear regression between BMI, WG and HOMA--IR and adiponectin (Beta = -0.022, -0.019 and -0.042), leptin (Beta = 0.154, 0.069 and 0.039) and TNF-α ( Beta = -0.082, 0.018 and 0.654), there were different association of BMI, WC and HOMA-IR in the different adipocytokines.
Conclusion: There is significant difference for the distribution of obesity, HOMA-IR and its related adipocytokines between two nationality pupils of Yanbian area. BMI, WC and HOMA-IR have different association in the different adipocytokines, and the association of BMI and WC in leptin is stronger than that of HOMA-IR, and that of HOMA-IR in TNF-α and adiponectin is stronger than that of BMI and WC.
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