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Oscillatory mechanoluminescence of Mn-doped SrZnOS in dynamic response to rapid compression.
Nat Commun
January 2025
Center for High Pressure Science and Technology Advanced Research, Beijing, 100093, China.
Photon emission may be continuously produced from mechanical work through self-recoverable mechanoluminescence (ML). Significant progress has been made in high-performance ML materials in the past decades, but the rate-dependent ML kinetics remains poorly understood. Here, we have conducted systematic studies on the self-recoverable ML of Mn-doped SrZnOS (SrZnOS: Mn) under rapid compression up to ~10 GPa.
View Article and Find Full Text PDFNew treatments for glaucoma.
Curr Opin Ophthalmol
January 2025
New York Eye Surgery Center, New York City, New York, USA.
Purpose Of Review: This review highlights new Federal Drug Administration (FDA) approved glaucoma treatments to familiarize providers with immediately available options.
Recent Findings: New FDA-approved treatments include the bimatoprost implant, travoprost implant, direct selective laser trabeculoplasty (DSLT), and ocular pressure adjusting pump. The bimatoprost implant is approved for a single administration with effects lasting for about 1 year, as opposed to the nearly 3-year effect for the travoprost implant.
Biomarkers.
Alzheimers Dement
December 2024
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Background: Cerebral small vessel disease (cSVD), as defined by neuroimaging characteristics such as white matter hyperintensities (WMHs), cerebral microhemorrhages (CMHs), and lacunar infarcts, is highly prevalent and has been associated with dementia risk and other clinical sequelae. Although risk factors for cSVD have been identified, little is known about the biological processes and molecular mediators that influence cSVD development and progression.
Methods: Within the Atherosclerosis Risk in Communities (ARIC) study, we used SomaScan Multiplexed Proteomic technology to relate 4,877 plasma proteins to concurrently measured MRI-defined cSVD characteristics, including WMHs, CMHs, and lacunar infarcts, in late-life (n=1508; mean age: 76).
Background: Prior research suggests living in an advantaged community in childhood is protective for late-life cognition and MRI-derived markers of brain health, independent of individual socioeconomic status. We examined the extent to which this effect is mediated by midlife hypertension status.
Method: KHANDLE and STAR are racially/ethnically diverse cohorts of older adults residing in northern California.
Biomarkers.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Stiffening of the large elastic arteries is an emerging age-related risk factor for Alzheimer's disease (AD) and related dementia (ADRD). Arterial stiffness is associated with pathological changes underlying AD/ADRD, and total arterial stiffness (T-PWV) can be subdivided into two main mechanisms. Structural stiffening (S-PWV) is due to intrinsic remodeling of the artery wall, and load-dependent stiffening (LD-PWV) is due to increased blood pressure without intrinsic changes to the artery wall.
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