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Low molecular weight chitosan (LMWC) was obtained by the enzymolysis of chitosan by papain. Enzymolysis conditions (initial chitosan concentration, temperature, pH and ratio of papain to chitosan) were optimized by conducting experiments at three different levels using the response surface methodology (RSM) to obtain high soluble reducing sugars (SRSs) concentrations. Meanwhile, the influence of chitosan substrate concentration on the activity of papain was assessed in the experiments. The enzymolysis process was analyzed using pseudo-first-order and pseudo-second-order kinetic models and the experiment data were found to be more consistent with the pseudo-second-order kinetic model. In addition, the kinetic behavior of the enzymolysis was also investigated by using Haldane model, and chitosan exhibited substrate inhibition. It was clear that the Haldane kinetic model adequately described the dynamic behavior of the chitosan enzymolysis by papain. When the initial chitosan concentration was above 8.0g/L, the papain was overloaded and exhibited significant inhibition.
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http://dx.doi.org/10.1016/j.carbpol.2015.08.052 | DOI Listing |
Mol Pharm
November 2024
School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Carbohydr Polym
September 2023
Department of Blood Transfusion, The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China; Department of Clinical Hematology, School of Clinical Laboratory Science, Guizhou Medical University, Guiyang 550001, China. Electronic address:
Diabetes is generally accompanied by difficult-to-heal wounds, which often lead to permanent disability and even death of patients. Because of the abundance of a variety of growth factors, platelet rich plasma (PRP) has been proven to have great clinical potential for diabetic wound treatment. However, how to suppress the explosive release of its active components while realizing adaptability to different wounds remains important for PRP therapy.
View Article and Find Full Text PDFBiotechnol Appl Biochem
June 2023
State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin, China.
Chitooligosaccharides (COS), an important biological functional component, are mainly extracted from marine products, but its raw materials are currently facing challenges such as marine resources pollution and demineralization. This study aimed to explore Trichoderma asperellum as a novel source to prepare COS. The COS were prepared by the enzymatic degradation of chitosan from T.
View Article and Find Full Text PDFWorld J Microbiol Biotechnol
July 2022
Institute of Bioengineering of Federal Research Center "Fundamentals of Biotechnology" of Russian Academy of Sciences, 7, bld. 1, 60 let Oktyabrya prospect, Moscow, Russia, 117312.
The article proves the ability of the entomopathogenic strain B. thuringiensis var. dendrolimus B-387 to high the constitutive production (3-12.
View Article and Find Full Text PDFBiotechnol Appl Biochem
February 2023
State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, People's Republic of China.
This study aimed to explore the structure and antibacterial properties of chitooligosaccharide monomers with different polymerization degrees and to provide a theoretical basis for inhibiting Salmonella infection. Chitosan was used as a raw material to prepare and separate low-molecular-weight chitooligosaccharides. Chitobiose, chitotriose, and chitotetraose were obtained by gradient elution with cation exchange resin.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!