AI Article Synopsis
- Elderflowers have been historically recognized for their anti-inflammatory effects and used to treat ailments like colds and flu.
- The study focused on understanding the connection between the structure of pectic-polysaccharides in elderflowers and their ability to modulate immune responses.
- The findings indicated that specific sugar linkages enhance the flowers’ immunomodulating activity, as changes in their structure (such as removal of certain sugars) affected their bioactivity, but no cytotoxicity was detected.
Article Abstract
Elderflowers have traditionally been used and are still used for its anti-inflammatory property. Traditionally elderflowers were used as remedies against cold, flu and diuretic. The aim of this study was to relate the structure of pectic-polysaccharides from elderflowers to immunomodulating properties. Purified fractions obtained by gelfiltration and ion exchange chromatography of 50% ethanol, 50°C water and 100°C water extracts exhibited strong complement fixating activity and macrophage stimulating activity. Reduced bioactivity was observed after removal of arabinose and 1,3,6-Gal linkages by weak acid hydrolysis. Enhanced bioactivity was observed after removal of estergroups by NaOH. Relating linkage analysis to the results of the bioactivity tests, led to the assumption that the branched moieties of the arabinogalactans linked to rhamnogalacturonan region, is important for the immunomodulating activity seen in elderflowers. No cytotoxity was observed.
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| http://dx.doi.org/10.1016/j.carbpol.2015.08.056 | DOI Listing |
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