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Effects of a helium/oxygen mixture on individuals' lung function and metabolic cost during submaximal exercise for participants with obstructive lung diseases. | LitMetric

AI Article Synopsis

  • Helium/oxygen therapies are being researched for treating symptoms of obstructive lung diseases, but past clinical trials have shown mixed results.
  • A study compared helium/oxygen (78%/22%) to medical air in healthy individuals and those with asthma or COPD while measuring various respiratory and cardiac parameters during rest and exercise.
  • While asthmatics showed a significant reduction in metabolic cost when using helium/oxygen, no overall differences were found for ventilatory and cardiac responses, highlighting the variability in individual responses as a major obstacle to using this therapy more widely.

Article Abstract

Background: Helium/oxygen therapies have been studied as a means to reduce the symptoms of obstructive lung diseases with inconclusive results in clinical trials. To better understand this variability in results, an exploratory physiological study was performed comparing the effects of helium/oxygen mixture (78%/22%) to that of medical air.

Methods: The gas mixtures were administered to healthy, asthmatic, and chronic obstructive pulmonary disease (COPD) participants, both moderate and severe (6 participants in each disease group, a total of 30); at rest and during submaximal cycling exercise with equivalent work rates. Measurements of ventilatory parameters, forced spirometry, and ergospirometry were obtained.

Results: There was no statistical difference in ventilatory and cardiac responses to breathing helium/oxygen during submaximal exercise. For asthmatics, but not for the COPD participants, there was a statistically significant benefit in reduced metabolic cost, determined through measurement of oxygen uptake, for the same exercise work rate. However, the individual data show that there were a mixture of responders and nonresponders to helium/oxygen in all of the groups.

Conclusion: The inconsistent response to helium/oxygen between individuals is perhaps the key drawback to the more effective and widespread use of helium/oxygen to increase exercise capacity and for other therapeutic applications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590345PMC
http://dx.doi.org/10.2147/COPD.S88965DOI Listing

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