In this issue of Blood, Mankelow et al link phosphatidylserine (PS) exposure in sickle erythrocytes to a physiological event in reticulocyte maturation. This discovery has implications for efforts to prevent thrombosis in sickle cell disease (SCD).
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| http://dx.doi.org/10.1182/blood-2015-08-665117 | DOI Listing |
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Impact of Variants, Epidemiological Trends, and Comorbidities on Hospitalization Rates of Unvaccinated Children in Brazil: A Retrospective Study (2020-2022).
Influenza Other Respir Viruses
December 2024
Infectious Diseases Division, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil.
This retrospective study aimed to investigate the impact of the emergence of new variants and the epidemiological scenario on hospitalization rates of unvaccinated children (0-12 years) in Brazil. The study included 1614 children admitted to a hospital between March 2020 and December 2022 but 101 (6.3%) of them testing positive for COVID-19 via RT-PCR.
View Article and Find Full Text PDFPlanning antepartum directed donations in preparation for neonatal cardiac surgery in the absence of compatible donors.
Transfusion
December 2024
Transfusion Medicine, Héma-Québec, Montréal, Québec, Canada.
Background: Homozygous inheritance of the R haplotype, characterized by the absence of the high frequency antigen Sec, as well as partial C and e antigens, is rare and is associated with potential for alloimmunization. Anti-Sec has been reported to be associated with a risk of delayed hemolytic transfusion reaction and hemolytic disease of the fetus and newborn (HDFN).
Results: We report the case of a 36-year-old pregnant woman with known sickle cell trait (SCT) and homozygous for the R haplotype with anti-Sec, anti-c, and anti-e.
Prevalence and Predictive Factors of Sickle Cell Emergencies Readmission in the Clinical Hematology Department of Dakar, Senegal.
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November 2024
Hematology Department, Cheikh Anta Diop University, Dakar, Senegal.
Article Synopsis
- Sickle cell emergencies are a leading reason for hospitalizations in patients with sickle cell disease, causing significant financial strain and increased health risks.
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Exp Hematol
November 2024
Department of Pharmaceutical Sciences, University of Illinois College of Pharmacy, Chicago, IL; Comprehensive Sickle Cell Center, University of Illinois Chicago, Chicago, IL; Jesse Brown Veteran's Administration Medical Center, Chicago, IL; Department of Neurology & Rehabilitation, University of Illinois College of Medicine, Chicago, IL; Department of Biomedical Engineering, University of Illinois College of Engineering, Chicago, IL. Electronic address:
Article Synopsis
- Patients with sickle cell disease (SCD) experience variable pain, making management difficult; this study focuses on the role of the 5-HT1A receptor gene (HTR1A) in pain variability.
- Researchers genotyped four HTR1A variants in 131 African American SCD patients and found three variants significantly associated with acute crisis pain, with effects differing between males and females.
- The study highlights that specific genetic variants can influence pain experiences in SCD, emphasizing the need for sex-based considerations in pain management strategies.
Article Synopsis
- * National guidelines suggest using standardized pain management strategies in the ED, but there is currently no uniform method for creating personalized pain management plans.
- * The article introduces an opioid calculator designed to assist clinicians in developing tailored pain management plans for better treatment of acute VOEs in SCD patients in the ED.
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