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Dibromomaleimide as a facile, versatile linker for delivery applications.
Ther Deliv
September 2016
Department of Chemistry & Biochemistry, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USA.
Reducible, dibromomaleimide-linked polymers for gene delivery.
Biomater Sci
January 2015
University of Washington, Department of Bioengineering and Molecular Engineering and Sciences Institute, William H. Foege Building, Box 355061, 3720 15th Ave NE, Seattle, WA 98195, USA.
Polycations have been successfully used as gene transfer vehicles both in vitro and in vivo; however, their cytotoxicity has been associated with increasing molecular weight. Polymers that can be rapidly degraded after internalization are typically better tolerated by mammalian cells compared to their non-degradable counterparts. Here, we report the use of a dibromomaleimide-alkyne (DBM-alkyne) linking agent to reversibly bridge cationic polymer segments for gene delivery and to provide site-specific functionalization by azide-alkyne cycloaddition chemistry.
View Article and Find Full Text PDFA novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.
Org Biomol Chem
April 2015
Department of Chemistry, University College London, 20 Gordon Street, London, UK.
Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones.
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