AI Article Synopsis
- Heat shock proteins (HSPs) are important molecular chaperones linked to the prognosis of esophageal cancer, but studies have shown mixed results, prompting this meta-analysis.
- The analysis reviewed data from 9 studies involving 801 patients, finding that lower levels of HSP27 and HSP70 were tied to significantly higher risks of death in patients, particularly in those with esophageal squamous cell carcinoma (ESCC).
- Results highlighted a 2.93 times greater risk of death for HSP27 negative patients compared to those positive for HSP27, and a 2.83 times greater risk for lower HSP70 levels, indicating that reduced expression of these proteins may serve as potential indicators of poor survival
Article Abstract
Purpose: Heat shock proteins (HSPs) are highly conserved molecular chaperones. There are various studies that assess the prognostic value of HSPs in patients with esophageal cancer, but the conclusion remains controversial. This is the first meta-analysis study aiming to summarize the evidence on the suitability of HSPs to predict patients' survival.
Materials And Methods: Searching PubMed, Web of science and Medline until May 31, 2014, data were compared for overall survival in patients with down-regulated HSPs level with those with up-regulated level. We conducted a meta-analysis of 9 studies (801 patients) that correlated HSPs levels with overall survival. Data were synthesized with hazard ratios (HRs).
Results: The estimated risk of death was 2.93-fold greater in HSP27 negative patients than HSP27 positive patients [95% confidence interval (CI), 1.12-7.62]. When limited to esophageal squamous cell carcinoma (ESCC), the risk of death in HSP27 negative patients seemed more significant (HR, 3.90; 95% CI, 2.35-6.49). Decreased expression of HSP70 was also associated with worse survival in esophageal cancer (HR, 2.83; 95% CI, 1.90-4.23) and, when limited to ESCC, HR was 3.21 (95% CI, 1.94-5.30). Data collected, however, were not sufficient to determine the prognostic value of HSP90 in patients with ESCC nor esophageal adenocarcinomas (EADC).
Conclusion: In this meta-analysis, reduced HSP27 and HSP70 expressions were associated with poor survival in patients with esophageal cancer, especially esophageal squamous cell carcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630035 | PMC |
| http://dx.doi.org/10.3349/ymj.2015.56.6.1497 | DOI Listing |
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