AI Article Synopsis
- Macrolide antimicrobials are frequently used to treat respiratory tract infections, but rising resistance limits their effectiveness.
- Macrolides not only fight infections but also have immune-modulating effects that could improve survival in various inflammatory conditions.
- The review examines the effectiveness, mechanisms, and side effects of macrolides in treating community-acquired pneumonia, while also addressing research challenges and providing treatment recommendations.
Article Abstract
Macrolide antimicrobials are commonly prescribed, specifically for the treatment of respiratory tract infections. Although still effective, the development of widespread macrolide resistance has limited their use. Aside from their antimicrobial effects, macrolides are also known to possess immune-modulatory properties which may confer a survival benefit in both acute and chronic inflammatory states. This review discusses the efficacy, potential mechanisms, and adverse effects of macrolide therapy specifically in community-acquired pneumonia in outpatients, hospitalized ward patients, and those requiring intensive care unit admission. Challenges for ongoing research in this field are discussed and treatment recommendations offered.
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| http://dx.doi.org/10.1007/s11908-015-0507-4 | DOI Listing |
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