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Light-triggered chemical amplification to accelerate degradation and release from polymeric particles. | LitMetric

Light-triggered chemical amplification to accelerate degradation and release from polymeric particles.

Chem Commun (Camb)

Department of NanoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA. and Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA.

Published: December 2015

AI Article Synopsis

Article Abstract

We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819761PMC
http://dx.doi.org/10.1039/c5cc06143aDOI Listing

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