We investigated the appropriateness of several methods, including those recommended in the Aquatic Guidance Document of the European Food Safety Authority (EFSA), for the derivation of chronic Tier-1 regulatory acceptable concentrations (RACs) for insecticides and aquatic organisms. The insecticides represented different chemical classes (organophosphates, pyrethroids, benzoylureas, insect growth regulators, biopesticides, carbamates, neonicotinoids, and miscellaneous). Chronic Tier-1 RACs derived using toxicity data for the standard species Daphnia magna, Chironomus spp., and/or Americamysis bahia, were compared with Tier-3 RACs derived from micro- and mesocosm studies on basis of the ecological threshold option (ETO-RACs). ETO-RACs could be derived for 31 insecticides applied to micro- and mesocosms in single or multiple applications, yielding a total number of 36 cases for comparison. The chronic Tier-1 RACs calculated according to the EFSA approach resulted in a sufficient protection level, except for 1 neonicotinoid (slightly underprotective) and for several pyrethroids if toxicity data for A. bahia were not included. This latter observation can be explained by 1) the fact that A. bahia is the most sensitive standard test species for pyrethroids, 2) the hydrophobic properties of pyrethroids, and 3) the fact that long-term effects observed in (epi) benthic arthropods may be better explained by exposure via the sediment than via overlying water. Besides including toxicity data for A. bahia, the protection level for pyrethroids can be improved by selecting both D. magna and Chironomus spp. as standard test species for chronic Tier-1 derivation. Although protective in the majority of cases, the conservativeness of the recommended chronic Tier-1 RACs appears to be less than an order of magnitude for a relatively large proportion of insecticides when compared with their Tier-3 ETO-RACs. This may leave limited options for refinement of the chronic effect assessment using laboratory toxicity data for additional species. Integr Environ Assess Manag 2016;12:747-758. © 2015 SETAC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ieam.1719 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification of Potential Biomarkers and Therapeutic Targets for Periodontitis.
Int Dent J
November 2024
Department of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital, Southwest Medical University, Luzhou, Sichuan, China; School of Stomatology, Southwest Medical University, Luzhou, Sichuan, China; Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, The Affiliated Stomatology Hospital, Southwest Medical University, Luzhou, Sichuan, China; Institute of Stomatology, Southwest Medical University, Luzhou, Sichuan, China. Electronic address:
Article Synopsis
- Periodontitis is a chronic inflammatory disease that current treatments struggle to effectively manage, prompting research to identify new biomarkers and therapeutic targets using advanced genetic analysis techniques.
- The study utilized Mendelian randomization and single-cell analysis on large datasets to pinpoint 14 significant drug targets, classifying them into three tiers based on the strength of their association with periodontitis.
- Results indicated that certain targets showed varying levels of evidence, with some (like TEK and SPP1) posing potential side effects, and further analysis revealed specific enrichment of target genes in immune cells, suggesting their roles in the disease.
Hospitalized Advanced Heart Failure With Preserved vs Reduced Left Ventricular Ejection Fraction: A Global Perspective.
JACC Heart Fail
October 2024
Department of Cardiology, Attikon University Hospital, National Kapodistrian University of Athens Medical School, Athens, Greece. Electronic address:
Background: Outcomes of hospitalized patients with heart failure (HF) and characteristics of advanced HF stage may vary across left ventricular ejection fraction (LVEF) and world regions.
Objectives: This study sought to analyze characteristics of hospitalized advanced HF patients across LVEF spectrum, world regions, and country income.
Methods: Among 18,553 hospitalized patients with acute HF (7,902 new-onset HF and 10,651 decompensated chronic HF) enrolled in the global registry REPORT-HF (International Registry to Assess Medical Practice With Longitudinal Observation for Treatment of Heart Failure), we analyzed characteristics and outcomes of patients with advanced HF, defined as previously diagnosed HF; severe symptoms before current admission (NYHA functional class III/IV); and ≥1 HF-related hospitalization in the preceding 12 months, excluding the current.
Molecular Thumbprints: Biological Signatures That Measure Loss of Identity.
Biomolecules
October 2024
Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada.
Each life is challenged to adapt to an ever-changing environment with integrity-simply put, to maintain identity. We hypothesize that this mission statement of adaptive homeostasis is particularly poignant in an adaptive response, like inflammation. A maladaptive response of unresolved inflammation can seed chronic disease over a lifetime.
View Article and Find Full Text PDFInternational Clinical Practice Guideline Recommendations for Acute Pulmonary Embolism: Harmony, Dissonance, and Silence.
J Am Coll Cardiol
October 2024
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- Despite advancements in clinical practices, pulmonary embolism (PE) remains a significant challenge in diagnosis and treatment due to factors like aging populations and health disparities.
- Clinicians often rely on various international guidelines for managing PE, but inconsistencies and gaps in recommendations can lead to confusion.
- This review focuses on key similarities and differences in PE guidelines and emphasizes the need for clearer management strategies and further research in this area.
Residential exposure to spp is associated with exacerbations in COPD.
Eur Respir J
November 2024
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
Background: Sensitisation to is linked to worse outcomes in patients with COPD; however, its prevalence and clinical implications in domestic (residential) settings remains unknown.
Methods: Individuals with COPD (n=43) recruited in Singapore had their residences prospectively sampled and assessed by shotgun metagenomic sequencing including indoor air, outdoor air and touch surfaces (a total of 126 specimens). The abundance of environmental and the occurrence of (Asp f) allergens in the environment were determined and immunological responses to allergens determined in association with clinical outcomes including exacerbation frequency.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!