AI Article Synopsis
- The text discusses a method for C-H alkylation using rhodium(III) catalysts to modify N-heterocycles like indolines, carbazoles, and pyrroles.
- This process employs common allylic alcohols to create new chemical structures.
- The resulting compounds feature a β-aryl carbonyl group, which is important for the development of biologically active molecules.
Article Abstract
The rhodium(III)-catalyzed site-selective C-H alkylation of various N-heterocycles, such as indolines, carbazoles, and pyrroles with readily available allylic alcohols is described. This protocol allows the generation of a heterocyclic scaffold containing a β-aryl carbonyl moiety, which is known to be a crucial structural unit of biologically active compounds.
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| http://dx.doi.org/10.1021/acs.joc.5b01696 | DOI Listing |
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