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KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary.
Kidney Int
February 2025
Institute of Physiology, University of Zurich, Zurich, Switzerland; Division of Nephrology, Cliniques universitaires Saint-Luc, UCLouvain Medical School, Brussels, Belgium. Electronic address:
The Kidney Disease: Improving Global Outcomes (KDIGO) 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) represents the first KDIGO guideline on this subject. Its scope includes nomenclature, diagnosis, prognosis, and prevalence; kidney manifestations; chronic kidney disease (CKD) management and progression, kidney failure, and kidney replacement therapy; therapies to delay progression of kidney disease; polycystic liver disease; intracranial aneurysms and other extrarenal manifestations; lifestyle and psychosocial aspects; pregnancy and reproductive issues; pediatric issues; and approaches to the management of people with ADPKD. The guideline has been developed with patient partners, clinicians, and researchers around the world, with the goal to generate a useful resource for healthcare providers and patients by providing actionable recommendations.
View Article and Find Full Text PDFAssociations Between Prenatal Dioxin-like Polychlorinated Biphenyls Exposure and Glucocorticoid and Androgenic Hormones in Umbilical Cord Blood.
Environ Res
January 2025
Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University. Zhengzhou, Henan, China. Electronic address:
This study investigates the association between prenatal exposure to dioxin-like polychlorinated biphenyls (DL-PCBs) and glucocorticoid and androgenic hormone levels in cord blood. We analyzed cord blood samples from 500 mother-infant pairs from China (2022-2023), focusing on hormones including cortisol, cortisone, dehydroepiandrosterone (DHEA), and androstenedione. The main analysis revealed significant reductions in cortisol levels with increased exposure to PCB-77 (β = -3.
View Article and Find Full Text PDFPreconception GLP-1 Receptor Agonist Use Associated with Decreased Risk for Adverse Obstetric Outcomes.
Am J Obstet Gynecol
January 2025
Department of Obstetrics and Gynecology, University Hospitals Cleveland Medical Center, Cleveland OH; Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH. Electronic address:
Background: The use of glucagon-like-peptide-1 receptor agonists (GLP-1RAs) has greatly increased in patients of reproductive age within the past four years. However, there is minimal research into the long-term impact of these medications on future pregnancies.
Objectives: We aimed to evaluate the association between adverse obstetric outcomes and antecedent GLP-1RA use using a nationally representative database.
The microcirculation : master in normal pregnancy, puppet in preeclampsia.
Am J Obstet Gynecol
January 2025
Hasselt University, Faculty of Medicine and Life Sciences, Agoralaan, 3590 Diepenbeek, Belgium; Department of Obstetrics and Gynaecology, ZOL Genk, campus St. Jan, Schiepse Bos 6, 3600 Genk, Belgium.
Objective: To investigate the association between functional parameters of the microcirculation and the systemic cardiovascular system in a population of pregnant women at risk for gestational hypertension disorders.
Study Design: For this observational study, women at high cardiovascular risk according to maternal anthropometrics, obstetric and medical history, were recruited at random gestational age depending on time of referral to the outpatient clinic for high risk prenatal care at Ziekenhuis Oost Limburg, Genk Belgium. After birth, data of maternal and neonatal outcome were obtained from the hospital records: only women with normal pregnancy (n = 142) and with preeclampsia (n = 34) were included in this analysis.
Incidence and characteristics of sudden sensorineural hearing loss during pregnancy and the postpartum period: A nationwide population-based study using customized cohort data.
Am J Otolaryngol
January 2025
Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. Electronic address:
Purpose: This study aimed to investigate the incidence and characteristics of sudden sensorineural hearing loss (SSNHL) in pregnant and non-pregnant women using the Korean National Health Insurance Service customized cohort data.
Materials And Methods: We defined the delivery group as women aged 15-49 years with International Classification of Diseases 10th Revision codes O80-O84 indicating delivery between January 2013 and December 2019. The control group was selected from individuals in the same age range without a history of delivery during the same period.
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