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Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes: A Randomized Clinical Trial.
JAMA
January 2025
Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
Importance: Metformin and glyburide monotherapy are used as alternatives to insulin in managing gestational diabetes. Whether a sequential strategy of these oral agents results in noninferior perinatal outcomes compared with insulin alone is unknown.
Objective: To test whether a treatment strategy of oral glucose-lowering agents is noninferior to insulin for prevention of large-for-gestational-age infants.
Unveiling nature's antidiabetic potential in Berberis orthobotrys seeds for alloxan-induced diabetic rats.
Sci Rep
January 2025
Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
To illustrate the anti-diabetic properties of Berberis orthobotrys seeds was the aim of the current study. After a series of experiments, two doses of aqueous methanolic extract of the seeds were selected i.e.
View Article and Find Full Text PDFABCC8 polymorphisms rs757110 and rs1801261 association with sulfonylurea therapy of Iraqi type 2 diabetics.
Wiad Lek
December 2024
DEPARTMENT OF CLINICAL LABORATORY SCIENCES, FACULTY OF PHARMACY, UNIVERSITY OF KUFA, KUFA, IRAQ.
Objective: Aim: Our study aimed to investigate the connection between the ABCC8 gene polymorphisms (rs1801261 and rs757110) and T2DM in the Iraqi Middle Euphrates region. Patients with type 2 diabetes were chosen because they were treated with glibenclamide and glimepiride.
Patients And Methods: Materials and Methods: The groups of this case-control study are the control group obviously healthy persons included 400 (235 Male/165 Female) and 400 T2DM group (213 Male/ 187 Female).
Loss-of-function (LOF) mutations in KATP channels cause hyperexcitability and insulin hypersecretion, resulting in congenital hyperinsulinism (CHI). Paradoxically, despite the initial insulin hypersecretion, many CHI cases, as well as KATP knockout (KO) animals, eventually 'crossover' to undersecretion and even diabetes. Here we confirm that Sur1 KO islets exhibit higher intracellular [Ca2+] ([Ca2+]i) at all [glucose], but show decreased glucose-stimulated insulin secretion.
View Article and Find Full Text PDFCOVID-19 is associated with high blood glucose levels: diabetic neuropathy during the SARS-CoV-2 pandemic: a case report.
Ann Med Surg (Lond)
December 2024
Pharmacy Department, All Africa Leprosy, Tuberculosis and Rehabilitation Training Centre, Zenebework, Kolfe Keranio, Addis Ababa, Ethiopia.
Introduction And Importance: The nerves in the legs and feet are most frequently damaged by diabetic neuropathy. The COVID-19 infection is associated with a high risk of neuropathy symptoms.
Case Presentation: On 12 July 2022, a 58-year-old black female retiree with significant symptoms of numbness and muscle weakness in the hands and legs was brought into the emergency room.
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