AI Article Synopsis
- The study aimed to assess the effectiveness of human recombinant endostatin (Endostar®) in combination with cisplatin doublets for treating advanced non-small cell lung cancer (NSCLC) and to use CT perfusion imaging for evaluating outcomes.
- Conducted from April 2011 to September 2014, 76 NSCLC patients were split into two groups: one received Endostar® before chemotherapy (group A), while the other received it from the start of treatment (group B).
- Results showed a statistically significant difference in treatment effectiveness between the two groups, with group A showing better outcomes; CT perfusion imaging proved useful for assessing the results, while adverse reactions were similar in both groups.
Article Abstract
Aims: To study the effectiveness of human recombinant endostatin injection (Endostar®) combined with cisplatin doublets in treating advanced non-small cell lung cancer (NSCLC), and to evaluate outcome by CT perfusion imaging.
Methods: From April 2011 to September 2014, 76 patients with advanced NSCLC who were treated with platinum-based doublets were divided into group A (36 patients) and group B (40 patients). Endostar® 15 mg/day was administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A, and combined with chemotherapy from the first day in Group B. Endostar® in the two groups was injected intravenously for 14 days.
Results: Treatment effectiveness in the two groups differed with statistical significance (p<0.05). Effectiveness evaluated by CT perfusion imaging, BF, BV, MTT and PS also demonstrated significant differences (all p<0.05). Adverse reactions in the two groups did not significantly vary (p>0.05).
Conclusions: The response rate with Endostar® administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A was better than Endostar® combined with chemotherapy from the first day, and CT perfusion imaging could be a reasonable method for evaluation of patient outcomes.
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| http://dx.doi.org/10.7314/apjcp.2015.16.15.6765 | DOI Listing |
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