AI Article Synopsis
- The research aimed to improve how well betulin, a compound from birch bark, dissolves and is absorbed in water.
- They created an ultrafine version of betulin using freeze-drying with polyethylene glycol and β-glycine.
- This new formulation released betulin much faster into water compared to both the original betulin and a version made by ball-milling with polyethylene glycol.
Article Abstract
The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.
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