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Corneal cross-linking.
Prog Retin Eye Res
December 2024
ELZA Institute, Webereistrasse 2, CH-8953, Dietikon, Switzerland; Laboratory for Ocular Cell Biology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206, Geneva, Switzerland. Electronic address:
First introduced over 20 years ago as a treatment for progressive keratoconus, the original "Dresden" corneal cross-linking (CXL) protocol involved riboflavin saturation of the stroma, followed by 30 min of 3 mW/cm-intensity ultraviolet-A (UV-A) irradiation. This procedure generates reactive oxygen species (ROS) that cross-link stromal molecules, thereby stiffening the cornea and counteracting the ectasia-induced weakening. Due to their large size, riboflavin molecules cannot readily pass through the corneal epithelial cell tight junctions; thus, epithelial debridement was performed.
View Article and Find Full Text PDFassessment of topically applied silver nanoparticles on entire cornea: comprehensive FTIR study.
Nanotoxicology
December 2024
Physics Department, Faculty of Science, Zagazig University, Zagazig, Egypt.
Silver nanoparticles (AgNPs) have gained attention in medicine for their potent antibacterial, antiviral, and anti-inflammatory properties. The use of silver nanoparticles in ophthalmic solutions raises concerns regarding potential toxicity of nanoparticles to ocular tissues, such as the cornea, conjunctiva, and retina, which necessitates further toxicity assessments aiding in the development of safer ophthalmic solutions. This study investigates the impact of AgNPs on corneal tissue using ophthalmic investigations, Fourier transform infrared (FTIR) spectroscopy, and chemometric analyses.
View Article and Find Full Text PDFA multimodal imaging approach to investigate retinal oxygen and vascular dynamics, and neural dysfunction in bietti crystalline dystrophy.
Microvasc Res
January 2025
Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology&Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Electronic address:
Background: This study aimed to explore retinal changes in Bietti crystalline dystrophy (BCD) patients, including retinal metabolism, blood flow, vascular remodeling, and pupillary light reflex (PLR) abnormalities.
Methods: This cross-sectional study included 120 eyes from BCD patients and 120 eyes from healthy controls, utilizing a multimodal imaging system (MEFIAS 3200, SYSEYE, Chongqing, China) to evaluate retinal oxygenation, blood flow, vascular structure, and PLR. Measurements included oxygen saturation, blood flow velocity, vessel diameters, and pulsatility metrics.
Role of traditional healers in the management of microbial keratitis in eastern Nepal.
Wellcome Open Res
November 2024
International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Background: Microbial Keratitis (MK) is a leading cause of corneal blindness due to infection and its consequences, with a higher incidence in resource-limited nations. Hospital-based patient records from different parts of Nepal suggest patients often use traditional eye medicine to treat MK. Traditional healers (TH) within the community are often the first point of care for MK management.
View Article and Find Full Text PDFPopulation Prevalence, Pattern and Associated Factors for Retinal Diseases at High Altitude in Nepal.
Clin Ophthalmol
September 2024
Department of Cornea, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Article Synopsis
- A study in high-altitude districts of Nepal aimed to evaluate the prevalence and factors related to retinal diseases among individuals aged 40 and older, highlighting the impact of hypoxia on eye health.
- Out of 338 participants, more than half were diagnosed with retinal disorders, with hypertensive retinopathy being the most prevalent condition, significantly linked to older age and hypertension.
- The findings indicate a need for improved access to eye care and education on managing hypertension among high-altitude populations to prevent and manage retinal diseases.
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