Objectives: The aim of this study was to assess cyber-user awareness of human infections with avian influenza A H7N9 in Zhejiang, China.
Methods: Daily Baidu index values were compared for different keywords, different periods (epidemic and non-epidemic), different levels of epidemic publicity (whether new cases were publicized), and different cities (divided into high, medium, low, and zero groups according to the number of cases). Furthermore, the correlation between the daily Baidu index values and the daily number of new cases was analyzed.
Results: Three epidemic periods (periods A/C/E) and three non-epidemic periods (periods B/D/F) were identified from April 2013 to May 2015 according to the curves of daily new cases. Each epidemic period was followed by a non-epidemic period. Baidu index values using 'H7N9' as a keyword were higher than the values using the keyword '' (avian influenza in Chinese) in earlier periods, but the situation reversed in later periods. Index values for 'H7N9' in the epidemic periods were higher than in the non-epidemic periods. In the first epidemic period (period A), the Baidu index values for 'H7N9' showed no difference between the different levels of epidemic publicity and had no correlation with the daily number of new cases. The index values in cities without reported cases showed no difference from the values recorded in the medium and low groups. However, a difference and a correlation were found in a later epidemic period.
Conclusions: The Baidu index would be a useful tool for assessing cyber-user awareness of an emerging infectious disease.
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http://dx.doi.org/10.1016/j.ijid.2015.09.017 | DOI Listing |
Front Psychiatry
December 2024
Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China.
Objectives: We aimed to assess the quality of information regarding depression on Chinese websites and popular video platforms.
Methods: We conducted searches on website platforms (Baidu, Bing) and video platforms (Bilibili, Douyin) using search terms "depression", "depressive disorder", "depression treatment", "depressive anxiety", "depressed patient", and "depressive symptoms". We collected the first 50 results with each search term in each platform.
Quant Imaging Med Surg
December 2024
Department of Cardiovascular Ultrasound, Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Background And Objective: About half of all heart failures are heart failures with preserved ejection fraction (HFpEFs). As the population ages and metabolic disorders become more common, the prevalence of HFpEF continues to increase annually. Patients with HFpEF typically show a decline in various reserve capacities after exercise.
View Article and Find Full Text PDFJ Ethnopharmacol
November 2024
Innovative Chinese Medicine Research Institute, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:
Ethnopharmacological Relevance: Epimedii Folium (Yinyanghuo) is a commonly used Chinese herb that plays a significant role in a lot of herbal formulae used to treat sexual dysfunction. Recently, an increasing amount of research on Epimedii Folium related to male reproductive dysfunction has been reported, and the exploration and application of Epimedium are also expanding rapidly. Flavonoids make up the vast majority of the chemical composition of Epimedii Folium, with small amounts of icarsides series, alkaloids, polysaccharide, volatile oils and other natural compounds.
View Article and Find Full Text PDFJ Ethnopharmacol
January 2025
Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, 712046, Shaanxi, PR China. Electronic address:
Eur J Med Chem
December 2024
State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China. Electronic address:
TLR4 signaling is instrumental in orchestrating multiple aspects of innate immunity. Developing small molecule inhibitors targeting the TLR4 pathway holds potential therapeutic promise for TLR4-related disorders. Herein, an artificial intelligence (AI)-powered next-generation screening approach, employing HelixVS and HelixDock, was utilized to focus on the TLR4-TLR4∗ (a second copy of TLR4) homodimerization surface, leading to the identification of a potent pyrazolo[1,5-a]pyrimidine derivative, designated as compound 1.
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